https://scholars.lib.ntu.edu.tw/handle/123456789/519558
標題: | The systems biology of neurofibromatosis type 1 - Critical roles for microRNA | 作者: | MING-JEN LEE Cho J.-H. Galas D.J. Wang K. |
公開日期: | 2012 | 卷: | 235 | 期: | 2 | 起(迄)頁: | 464-468 | 來源出版物: | Experimental Neurology | 摘要: | Neurofibromatosis type 1 (NF1) is one of the most common inherited neurological disorders with a wide range of clinical manifestations. The causative gene for NF1 encodes a multi-domain protein, neurofibromin, which interacts with RAS through its RAS-GAP domain. Dysfunction of neurofibromin results in abnormal RAS activation in the cells which has been thought to be the main process in the initiation and progression of NF1. Based on this hypothesis, inhibitors for various RAS mediated signaling pathways are in different stages of clinical trials to treat NF1 or NF1-associated symptoms. While the molecular genetics of NF1 has made significant progress in recent years, the underlying etiology and progression of NF1 are yet to be fully understood. Besides review and summarization of the latest results of genetic, transcriptomic and microRNA studies associated with NF1, we conducted limited post-hoc analysis to illustrate the importance of using integrated systems biology approach to study complex diseases like NF1. ? 2011 Elsevier Inc.. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84860364109&doi=10.1016%2fj.expneurol.2011.10.023&partnerID=40&md5=fd41d14dcc028b6faa694a285d9e7b08 https://scholars.lib.ntu.edu.tw/handle/123456789/519558 |
ISSN: | 0014-4886 | DOI: | 10.1016/j.expneurol.2011.10.023 | SDG/關鍵字: | growth associated protein; imatinib; methotrexate; mevinolin; microRNA; neurofibromin; peginterferon alpha2b; pirfenidone; rapamycin; Ras protein; vinblastine; clinical feature; clinical trial (topic); cognitive defect; disease association; gene; gene deletion; gene expression regulation; gene mutation; gene targeting; high throughput sequencing; histopathology; human; malignant peripheral nerve sheath tumor; molecular genetics; molecular interaction; neurofibroma; neurofibromatosis; neurofibromin 1 gene; neuropathology; nonhuman; phase 1 clinical trial (topic); photodynamic therapy; post hoc analysis; priority journal; protein domain; protein interaction; review; signal transduction; systems biology; transcriptomics; tumor growth; Animals; Gene Regulatory Networks; Humans; MicroRNAs; Neurofibromatosis 1; Signal Transduction; Systems Biology |
顯示於: | 醫學系 |
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