https://scholars.lib.ntu.edu.tw/handle/123456789/519914
標題: | Auditory event-related potential of subjects with suspected pre-psychotic state and first-episode psychosis | 作者: | MING-HSIEN HSIEH Shan, J.-C. Huang, W.-L. Cheng, W.-C. MING-JANG CHIU Jaw, F.-S. Hwu, H.-G. FU-SHAN JAW |
公開日期: | 2012 | 卷: | 140 | 期: | 43833 | 起(迄)頁: | 243-249 | 來源出版物: | Schizophrenia Research | 摘要: | Background: Recent schizophrenia research exploring the complicated pathogenesis of schizophrenia has focused on the subjects with at-risk mental states in order to exclude the influence of confounding factors. This study explores 3 sets of auditory-related event potentials in subjects with different risk levels of psychosis. Methods: Subjects were recruited from the SOPRES study in Taiwan. P50 and N100 using an auditory paired-click paradigm and duration MMN were assessed on 32 first-episode psychosis (FEP), 30 ultra-high risk (UHR), 37 E-BARS (early/broad at-risk mental states) participants and 56 controls. Results: MMN was correlated with neither P50 nor N100, whereas many parameters of the latter two were intercorrelated with each other. Compared to healthy controls, MMNs were significantly lower in all 3 clinical groups (E-BARS, UHR and FEP). A gradient of sensory-gating deficits, manifested by increased P50 ratios (S2/S1) and decreased N100 differences, across different levels of clinical severity was suggested by a linear trend. For the UHR subjects, P50 gating ratio, N100 gating ratio, N100 difference, and N100. S2 amplitude might be potential indicators to discriminate converters from non-converters. Conclusions: By including subjects with E-BARS, our results provide new insight regarding pre-attentive auditory event-related potential in subjects across different risk levels of psychotic disorders. Impaired deviance detection shown by MMNs already exists in people at a pre-psychotic state regardless of clinical severity, while sensory-gating deficits shown by P50/N100 varies depending on the risk levels in prodromal period. Further longitudinal research exploring the relationship between ERPs and subjects with a suspected pre-psychotic state is needed. ? 2012 Elsevier B.V. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84865340158&doi=10.1016%2fj.schres.2012.06.021&partnerID=40&md5=ff38f590f59d3f3286471cda67619dbc https://scholars.lib.ntu.edu.tw/handle/123456789/519914 |
ISSN: | 0920-9964 | DOI: | 10.1016/j.schres.2012.06.021 | SDG/關鍵字: | neuroleptic agent; adult; age distribution; amplitude modulation; article; attention; controlled study; disease severity; drug effect; evoked auditory response; female; high risk population; human; latent period; major clinical study; male; mental health; priority journal; psychologic assessment; psychosis; risk assessment; sensory gating; sex difference; Acoustic Stimulation; Adolescent; Adult; Contingent Negative Variation; Electroencephalography; Evoked Potentials, Auditory; Female; Humans; Male; Psychoacoustics; Psychotic Disorders; Reaction Time; Sensory Gating; Taiwan; Young Adult |
顯示於: | 醫學系 |
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