https://scholars.lib.ntu.edu.tw/handle/123456789/520011
標題: | Generation of induced pluripotent stem cells (IBMSi011-A) from a patient with Parkinson's disease carrying LRRK2 p.I1371V mutation | 作者: | Lin H.-I. Cheng Y.-C. Ko H.-W. Wen C.-H. Lu H.-E. Huang C.-Y. Hsieh P.C.H. CHIN-HSIEN LIN |
公開日期: | 2019 | 出版社: | Elsevier B.V. | 卷: | 37 | 來源出版物: | Stem Cell Research | 摘要: | Leucine rich repeat kinase 2 (LRRK2) is the causative gene for autosomal-dominant familial forms of Parkinson's disease (PD). Here, we generated induced pluripotent stem cells (iPSCs) from the peripheral blood mononuclear cells of a female patient with LRRK2 c.4111A > G (p.I1371V) mutation by using the Sendai-virus delivery system. The resulting iPSCs had a normal karyotype. The iPSCs also showed pluripotency confirmed by immunofluorescent staining and differentiated into the three germ layers in vivo. This cellular model will provide a platform for studying the role of LRRK2 in the disease process. ? 2019 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064537060&doi=10.1016%2fj.scr.2019.101447&partnerID=40&md5=0302a58845a54b34d1c31c3b6abce7e4 https://scholars.lib.ntu.edu.tw/handle/123456789/520011 |
ISSN: | 1873-5061 | DOI: | 10.1016/j.scr.2019.101447 | SDG/關鍵字: | complementary DNA; genomic DNA; leucine rich repeat kinase 2; octamer transcription factor 4; stage specific embryo antigen 4; leucine rich repeat kinase 2; LRRK2 protein, human; animal cell; animal tissue; Article; cell differentiation; enzyme activity; female; gene mutation; genetic stability; germ layer; human; human cell; immunofluorescence; induced pluripotent stem cell; karyotype; karyotyping; molecular pathology; mouse; nerve degeneration; neuropathology; nonhuman; Parkinson disease; peripheral blood mononuclear cell; priority journal; Sendai virus; short tandem repeat; animal; cell culture; cell differentiation; genetics; induced pluripotent stem cell; metabolism; middle aged; mononuclear cell; mutation; nonobese diabetic mouse; nuclear reprogramming; Parkinson disease; pathology; phenotype; SCID mouse; teratoma; Animals; Cell Differentiation; Cells, Cultured; Cellular Reprogramming; Female; Humans; Induced Pluripotent Stem Cells; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Leukocytes, Mononuclear; Mice; Mice, Inbred NOD; Mice, SCID; Middle Aged; Mutation; Parkinson Disease; Phenotype; Teratoma |
顯示於: | 醫學系 |
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