https://scholars.lib.ntu.edu.tw/handle/123456789/520062
標題: | Vitamin D receptor genetic variants and Parkinson's disease in a Taiwanese population | 作者: | CHIN-HSIEN LIN KAI-HSIANG CHEN Chen M.-L. Lin H.-I. RUEY-MEEI WU |
公開日期: | 2014 | 出版社: | Elsevier Inc. | 卷: | 35 | 期: | 5 | 起(迄)頁: | 1212.e11-3 | 來源出版物: | Neurobiology of Aging | 摘要: | Patients with Parkinson's disease (PD) have hypovitaminosis D status and genetic variants of vitamin D receptor (VDR) gene are recently shown to be associated with PD in a large-scale genome-wide association study in a Caucasian population. Few studies examined VDR genetic variants in large-scale Asian patients with PD. We therefore genotyped 6 VDR genetic variants in a total of 1492 Taiwanese subjects, including 700 patients with PD and 792 age and/or gender matched control subjects. We did not observe any significant associations between the studied genetic variants of VDR and the risk of PD. Our data suggest that genetic variations of the VDR gene did not play a major role in a Taiwanese PD population. Further studies of VDR and its interaction with serum vitamin D levels are warranted to clarify the potential role of vitamin D in PD pathogenesis. ? 2014. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84893750024&doi=10.1016%2fj.neurobiolaging.2013.10.094&partnerID=40&md5=03cb2cbfa33e4e28c4ce1cf817f0988f https://scholars.lib.ntu.edu.tw/handle/123456789/520062 |
ISSN: | 0197-4580 | DOI: | 10.1016/j.neurobiolaging.2013.10.094 | SDG/關鍵字: | vitamin D; vitamin D receptor; 5' untranslated region; adult; aged; article; controlled study; ethnic group; female; gene; gene frequency; gene function; genetic association; genetic variability; genotype; human; major clinical study; male; Parkinson disease; pathophysiology; priority journal; protein interaction; single nucleotide polymorphism; Taiwanese; VDR gene; very elderly; vitamin blood level; Parkinson's disease; Taiwan; Vitamin D; Vitamin D receptor gene; Adult; Aged; Aged, 80 and over; Asian Continental Ancestry Group; Case-Control Studies; Cohort Studies; Female; Genome-Wide Association Study; Humans; Male; Middle Aged; Parkinson Disease; Polymorphism, Genetic; Receptors, Calcitriol; Risk; Taiwan; Vitamin D |
顯示於: | 醫學系 |
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