https://scholars.lib.ntu.edu.tw/handle/123456789/520074
標題: | RIT2 variant is not associated with Parkinson's disease in a Taiwanese population | 作者: | CHIN-HSIEN LIN Chen M.-L. Yu C.-Y. RUEY-MEEI WU |
公開日期: | 2013 | 出版社: | Elsevier Inc. | 卷: | 34 | 期: | 9 | 起(迄)頁: | 2236.e1-3 | 來源出版物: | Neurobiology of Aging | 摘要: | Recent genome-wide association studies of Parkinson's disease (PD) have identified the rs12456492 variant of the novel susceptibility loci, RIT2, as being associated with disease risk in a large white population. Studies among Asians are scarce. We genotyped RIT2 rs12456492 variant in a total of 1000 participants, comprising 500 patients with PD and 500 control subjects in a Taiwanese population. The frequency of GA/AA genotype was slightly higher in PD patients compared with controls, but was without statistical significance (odds ratio= 1.03, 95% confidence interval= 0.73-1.46, p= 0.86). We failed to replicate the RIT2 rs12456492 variant as a genetic risk factor for PD in our population. ? 2013 Elsevier Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84878940562&doi=10.1016%2fj.neurobiolaging.2013.04.005&partnerID=40&md5=7760d6a303e02558bcee04e5517603a0 https://scholars.lib.ntu.edu.tw/handle/123456789/520074 |
ISSN: | 0197-4580 | DOI: | 10.1016/j.neurobiolaging.2013.04.005 | SDG/關鍵字: | adenine; guanine; levodopa; adult; aged; article; Caucasian; cohort analysis; controlled study; disease association; dyskinesia; ethnic difference; ethnic group; female; gene; gene frequency; gene locus; genetic association; genetic risk; genetic susceptibility; genetic variability; genotype; heterozygote; human; major clinical study; male; motor dysfunction; Parkinson disease; population based case control study; population genetics; priority journal; risk assessment; RIT2 gene; Taiwanese |
顯示於: | 醫學系 |
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