https://scholars.lib.ntu.edu.tw/handle/123456789/520082
標題: | LRRK2 Parkinson's disease: From animal models to cellular mechanisms | 作者: | CHIN-HSIEN LIN Tsai P.-I. RUEY-MEEI WU Chin C.-T. |
公開日期: | 2011 | 卷: | 22 | 期: | 4 | 起(迄)頁: | 411-418 | 來源出版物: | Reviews in the Neurosciences | 摘要: | Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) play a major role in the development of Parkinson's disease. The most frequently defined mutations of LRRK2 are located in the central catalytic region of the LRRK2 protein, suggesting that dysregulations of its enzymatic activities contribute to PD pathogenesis. Herein, we review recent progress in research concerning how LRRK2 mutations affect cellular pathways and lead to neuronal degeneration. We also summarize recent evidence revealing the endogenous function of LRRK2 protein within cells. These concepts can be used to further understand disease pathophysiology and serve as a platform to develop therapeutic strategies for the treatment of Parkinson's disease. ? 2011 by Walter de Gruyter Berlin Boston. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-80051707484&doi=10.1515%2fRNS.2011.036&partnerID=40&md5=4dbb537888304074aa0fcb98606b3eab https://scholars.lib.ntu.edu.tw/handle/123456789/520082 |
ISSN: | 0334-1763 | DOI: | 10.1515/RNS.2011.036 | SDG/關鍵字: | leucine rich repeat kinase 2; gene mutation; human; nerve degeneration; nonhuman; Parkinson disease; pathophysiology; priority journal; protein analysis; protein function; review; Animals; Disease Models, Animal; Humans; Models, Biological; Parkinson Disease; Protein-Serine-Threonine Kinases |
顯示於: | 醫學系 |
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