https://scholars.lib.ntu.edu.tw/handle/123456789/520135
標題: | Advanced Theory of Mind in patients at early stage of Parkinson's disease | 作者: | Yu R.-L. RUEY-MEEI WU MING-JANG CHIU CHUN-HWEI TAI CHIN-HSIEN LIN Hua M.-S. |
公開日期: | 2012 | 卷: | 18 | 期: | 1 | 起(迄)頁: | 21-24 | 來源出版物: | Parkinsonism and Related Disorders | 摘要: | Advanced Theory of Mind (ToM) refers to the sophisticated ability to infer other people's thoughts, intentions, or emotions in social situations. With appropriate advanced ToM, one can behave well in social interactions and can understand the intention of others' behavior. Prefrontal cortex plays a vital role in this ability, as shown in functional brain imaging and lesion studies. Considering the primary neuropathology of Parkinson's disease (PD) involving the frontal lobe system, patients with PD are expected to exhibit deficits in advanced ToM. However, few studies on this issue have been explored, and whether advanced ToM is independent of executive functions remains uncertain. Thirty-nine early non-demented PD patients and 40 normal control subjects were included. Both groups were matched in age, level of education, and verbal intelligence quotient. Each participant received advanced ToM, executive functions, and verbal intelligence quotient tests. We discovered that the performance of the PD patients on the Cartoon ToM task was significantly poorer than that of their normal counterparts. Correlation analysis revealed that performance scores of advanced ToM in PD patients were significantly associated with their executive functions scores; however, this is not the case for normal controls. We conclude that dysfunction of advanced ToM develops in early PD patients, who require more cognitive abilities than their normal counterparts to generate advanced ToM. Our findings might be helpful in developing educational and medical care programs for PD patients in the future. ? 2011 Elsevier Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84860412894&doi=10.1016%2fj.parkreldis.2011.08.003&partnerID=40&md5=fa9d55a96ce89ca88504dd986786a959 https://scholars.lib.ntu.edu.tw/handle/123456789/520135 |
ISSN: | 1353-8020 | DOI: | 10.1016/j.parkreldis.2011.08.003 | SDG/關鍵字: | levodopa; adult; article; clinical article; controlled study; depression; disease duration; executive function; female; functional neuroimaging; human; intelligence; male; neuropathology; onset age; Parkinson disease; priority journal; social cognition; theory of mind; Aged; Case-Control Studies; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Parkinson Disease; Theory of Mind |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。