https://scholars.lib.ntu.edu.tw/handle/123456789/520143
標題: | Feeling-of-knowing in episodic memory in patients with Parkinson's disease with various motor symptoms | 作者: | Yu R.-L. RUEY-MEEI WU CHUN-HWEI TAI CHIN-HSIEN LIN Hua M.-S. |
公開日期: | 2010 | 出版社: | John Wiley and Sons Inc. | 卷: | 25 | 期: | 8 | 起(迄)頁: | 1034-1039 | 來源出版物: | Movement Disorders | 摘要: | The aim of this study was to examine metamemory in patients with Parkinson's disease (PD) with different dominant motor symptoms. This is a prospective case-control study. Fifty-five PD patients [25 patients with tremor-dominant (TD) motor symptoms and 30 patients with akinetic and rigidity-dominant (ARD) motor symptoms] and 30 normal controls were studied. The two patient groups were similar in terms of age, level of education, disease duration, and disease severity. Metamemory was measured using the experimental metamemory task [feeling-of-knowing (FOK) paradigm]. In addition, memory and executive functions were determined using detailed cognitive tests. In comparison with normal subjects and TD patients, ARD patients exhibited impaired FOK accuracy (P = 0.007). Furthermore, correlation analysis revealed an intergroup differential pattern, which indicated that FOK accuracy was primarily related to memory ability in ARD patients and executive function in TD patients. Our results provide evidence of impaired metamemory in the early stages of PD with ARD rather than TD motor symptoms. These findings might be useful for designing specific medical care strategies for ARD patients. Further studies are needed to determine whether impaired metamemory is an early predictor for brain alteration in PD patients. ? 2010 Movement Disorder Society. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77953516321&doi=10.1002%2fmds.23017&partnerID=40&md5=c10244d39815efb5bc93a480a78462e2 https://scholars.lib.ntu.edu.tw/handle/123456789/520143 |
ISSN: | 0885-3185 | DOI: | 10.1002/mds.23017 | SDG/關鍵字: | accuracy; adult; akinesia; article; brain function; case control study; cognition; comparative study; controlled study; correlation analysis; demography; disease duration; disease severity; educational status; episodic memory; feeling of knowing; female; human; major clinical study; male; medical care; motor dysfunction; neuropsychological test; Parkinson disease; predictor variable; priority journal; prospective study; rigidity; task performance; tremor; aged; analysis of variance; complication; emotion; executive function; Memory Disorders; middle aged; nonparametric test; Parkinson disease; physiology; psychology; recall; statistics; Aged; Analysis of Variance; Emotions; Executive Function; Female; Humans; Male; Memory Disorders; Mental Recall; Middle Aged; Neuropsychological Tests; Parkinson Disease; Statistics as Topic; Statistics, Nonparametric |
顯示於: | 醫學系 |
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