https://scholars.lib.ntu.edu.tw/handle/123456789/520338
標題: | Risk factors for developing synchronous esophageal neoplasia in patients with head and neck cancer | 作者: | Wang W.-L. Lee C.-T. YI-CHIA LEE Hwang T.-Z. Wang C.-C. Hwang J.-C. Tai C.-M. Chang C.-Y. Tsai S.-S. CHENG-PING WANG JENG-YUH KO Lin J.-T. |
公開日期: | 2011 | 卷: | 33 | 期: | 1 | 起(迄)頁: | 77-81 | 來源出版物: | Head and Neck | 摘要: | Background This study investigated the risk factors for synchronous esophageal neoplasia in patients with head and neck squamous cell carcinoma (HNSCC). Methods All 315 consecutive patients with newly diagnosed HNSCC received endoscopic esophageal screening with image-enhanced endoscopy. Results Sixty-nine patients (21.9%) had synchronous esophageal neoplasia, 37 (53.6%) with superficial neoplasia and 21 (30.4%) with multiple esophageal lesions. Univariate analysis revealed age <50 years, drinking alcohol, and location of index HNSCC were significant risk factors for developing synchronous esophageal neoplasia. In multivariate analysis, drinking alcohol (odds ratio [OR], 3.792; p =.0035), index oropharynxgeal cancers (OR, 3.618; p =.0045) and hypopharyngeal cancers (OR, 2.627; p =.0029) were independent risk factors. Drinking alcohol was clearly dose-response related (p =.001). Conclusion Alcohol consumption and index tumor location are associated with the development of synchronous esophageal neoplasia in patients with HNSCC. Because of the high prevalence, routine endoscopic examination of the esophagus should be recommended, especially in patients with the risk factors identified. ? 2010 Wiley Periodicals, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-78651359461&doi=10.1002%2fhed.21397&partnerID=40&md5=f673347a1174c84e1098d9d5fcfdf5c5 https://scholars.lib.ntu.edu.tw/handle/123456789/520338 |
ISSN: | 1043-3074 | DOI: | 10.1002/hed.21397 | SDG/關鍵字: | adult; aged; alcohol consumption; article; cancer localization; cancer risk; cigarette smoking; clinical assessment; clinical trial; endoscopy; esophageal neoplasia; esophagus cancer; female; head and neck cancer; human; human tissue; hypopharynx cancer; major clinical study; male; nasopharynx cancer; oropharynx cancer; priority journal; prospective study; squamous cell carcinoma; Age Distribution; Aged; Analysis of Variance; Carcinoma, Squamous Cell; Cohort Studies; Confidence Intervals; Early Detection of Cancer; Esophageal Neoplasms; Esophagoscopy; Female; Head and Neck Neoplasms; Humans; Incidence; Male; Middle Aged; Multivariate Analysis; Neoplasms, Multiple Primary; Odds Ratio; Retrospective Studies; Risk Assessment; Sex Distribution; Survival Analysis; Taiwan |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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