https://scholars.lib.ntu.edu.tw/handle/123456789/520340
標題: | Secondary Prevention of Esophageal Squamous Cell Carcinoma in Areas Where Smoking, Alcohol, and Betel Quid Chewing are Prevalent | 作者: | Chung C.-S. YI-CHIA LEE CHENG-PING WANG JENG-YUH KO Wang W.-L. MING-SHIANG WU HSIU-PO WANG |
公開日期: | 2010 | 卷: | 109 | 期: | 6 | 起(迄)頁: | 408-421 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Esophageal cancer is ranked as the sixth most common cause of cancer death worldwide and has a substantial effect on public health. In contrast to adenocarcinoma arising from Barrett's esophagus in Western countries, the major disease phenotype in the Asia-Pacific region is esophageal squamous cell carcinoma which is attributed to the prevalence of smoking, alcohol, and betel quid chewing. Despite a multidisciplinary approach to treating esophageal cancer, the outcome remains poor. Moreover, field cancerization reveals that esophageal squamous cell carcinoma is closely linked with the development of head and neck cancers that further sub-optimize the treatment of patients. Therefore, preventive strategies are of paramount importance to improve the prognosis of this dismal disease. Since obstacles exist for primary prevention via risk factor elimination, the current rationale for esophageal cancer prevention is to identify high-risk groups at earlier stages of the disease, and encourage them to get a confirmatory diagnosis, prompt treatment, and intensive surveillance for secondary prevention. Novel biomarkers for identifying specific at-risk populations are under extensive investigation. Advances in image-enhanced endoscopy do not just substantially improve our ability to identify small precancerous or cancerous foci, but can also accurately predict their invasiveness. Research input from the basic sciences should be translated into preventive measures in order to decrease the disease burden of esophageal cancer. ? 2010 Formosan Medical Association & Elsevier. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77953664497&doi=10.1016%2fS0929-6646%2810%2960072-1&partnerID=40&md5=343a975560e811390fcc8f18be5baf4f https://scholars.lib.ntu.edu.tw/handle/123456789/520340 |
ISSN: | 0929-6646 | DOI: | 10.1016/S0929-6646(10)60072-1 | SDG/關鍵字: | alcohol consumption; betel nut; cancer diagnosis; cancer invasion; cancer prevention; cancer staging; cancer susceptibility; esophageal squamous cell carcinoma; esophagus cancer; head and neck cancer; high risk population; human; mastication; prediction; prognosis; review; risk factor; smoking; Adenocarcinoma; Alcohol Drinking; Areca; Asia; Barrett Esophagus; Carcinoma, Squamous Cell; Esophageal Neoplasms; Humans; Mastication; Pacific Islands; Prevalence; Risk Factors; Secondary Prevention; Smoking |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。