https://scholars.lib.ntu.edu.tw/handle/123456789/520470
標題: | The Use of Benzodiazepine Receptor Agonists and the Risk of Hospitalization for Pneumonia: A Nationwide Population-Based Nested Case-Control Study | 作者: | Chen T.-Y. Winkelman J.W. Mao W.-C. Liu C.-L. Hsu C.-Y. CHI-SHIN WU |
關鍵字: | benzodiazepine-receptor agonist; midazolam; pneumonia | 公開日期: | 2018 | 卷: | 153 | 期: | 1 | 起(迄)頁: | 161-171 | 來源出版物: | Chest | 摘要: | Background The relationship between the use of benzodiazepine-receptor agonists (BZRAs) and the risk of hospitalization for pneumonia remains inconclusive. This study aimed to explore the association between BZRA use and hospitalization for pneumonia in a general population. Methods This population-based nested case-control study used Taiwan's National Health Insurance Research Database between 2002 and 2012. We included only new users who did not have any BZRA prescriptions on record in the preceding 2 years and identified 12,002 subjects who were hospitalized for pneumonia (International Classification of Diseases, Ninth Revision codes 480-486, and 507) and 12,002 disease risk score-matched control subjects. A logistic regression model was used to determine the association of BZRA use and hospitalization for pneumonia. The exposure date, dose-response relationship, and class of BZRAs were comprehensively assessed. Results Current BZRA exposure was associated with hospitalization for pneumonia (adjusted OR [aOR],1.86; 95% CI, 1.75-1.97). Benzodiazepine hypnotic agents (aOR, 2.42; 95% CI, 2.16-2.71) had a higher risk of pneumonia than did benzodiazepine anxiolytic agents (aOR, 1.53; 95% CI, 1.44-1.63) or nonbenzodiazepine hypnotic agents (aOR, 1.60; 95% CI, 1.46-1.76). The pneumonia risk was increased with ultrashort-acting and short- to intermediate-acting agents, a higher defined daily dose, and the number of BZRAs used. Among individual BZRAs examined, midazolam had a higher risk (aOR, 5.77; 95% CI, 4.31-7.73) of hospitalization for pneumonia than did the others. Conclusions This study suggests that there is a dose-response relationship between current BZRA use and the risk of hospitalization for pneumonia. In addition, benzodiazepine hypnotic agents, especially midazolam, present a greater risk of hospitalization for pneumonia. These findings reinforce the importance of a careful analysis of the benefits vs the risks of BZRA use. ? 2017 American College of Chest Physicians |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85040169214&doi=10.1016%2fj.chest.2017.07.030&partnerID=40&md5=6529829043c6fd6afec082d2b14eac3f https://scholars.lib.ntu.edu.tw/handle/123456789/520470 |
ISSN: | 0012-3692 | DOI: | 10.1016/j.chest.2017.07.030 | SDG/關鍵字: | alprazolam; benzodiazepine receptor stimulating agent; bromazepam; brotizolam; chlordiazepoxide; clobazam; clonazepam; clorazepate; diazepam; estazolam; fludiazepam; flunitrazepam; flurazepam; lorazepam; lormetazepam; medazepam; midazolam; nimetazepam; nitrazepam; nordazepam; oxazepam; oxazolam; triazolam; zaleplon; zolpidem; zopiclone; 4 aminobutyric acid A receptor stimulating agent; anxiolytic agent; clonazepam; hypnotic sedative agent; adult; age; aged; Article; case control study; Charlson Comorbidity Index; controlled study; disease association; dose response; drug exposure; drug use; female; hospitalization; human; major clinical study; male; middle aged; pneumonia; population research; priority journal; risk; sex difference; chemically induced; hospitalization; pneumonia; register; risk factor; statistics and numerical data; Taiwan; young adult; Adult; Aged; Anti-Anxiety Agents; Case-Control Studies; Clonazepam; Female; GABA-A Receptor Agonists; Hospitalization; Humans; Hypnotics and Sedatives; Male; Middle Aged; Pneumonia; Registries; Risk Factors; Taiwan; Young Adult |
顯示於: | 流行病學與預防醫學研究所 |
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