https://scholars.lib.ntu.edu.tw/handle/123456789/520473
標題: | Use of antidepressants and risk of hospitalization for acute myocardial infarction: A nationwide case-crossover study | 作者: | CHI-SHIN WU Wu H.-T. Tsai Y.-T. Huang Y.-W. Tsai H.-J. |
關鍵字: | Acute myocardial infarction; Antidepressant use; Case-crossover | 公開日期: | 2017 | 卷: | 94 | 起(迄)頁: | 7-14 | 來源出版物: | Journal of Psychiatric Research | 摘要: | Background We aimed to investigate the association between antidepressant use and the risk of hospitalization for acute myocardial infarction (AMI). Methods A case-crossover study was conducted using a nationwide population-based sample from Taiwan's National Health Insurance Research Database. A total of 18,631 patients with incident AMI were included in this study. The effects of antidepressant use as well as that of various classes (including tricyclic or tetracyclic antidepressants; selective serotonin reuptake inhibitors; or serotonin norepinephrine reuptake inhibitors), doses, and receptor-binding profiles of the antidepressants on AMI were assessed. Conditional logistic regression models with adjustment for potential confounding factors were applied to determine the effects of antidepressant use on the risk of AMI during case and control time periods of 15, 30, and 60 days, respectively. The modifiable effects of age, gender, and comorbidity were evaluated by stratified analysis. Results Antidepressant use was not associated with the risk of AMI (adjusted odds ratio [AOR] = 1.04; 95% confidence interval (CI): 0.88–1.24). Likewise, neither the class, dose, nor the binding affinity of serotonin transporter or norepinephrine transporter was associated with AMI risks, and there was no modifying effect of age, gender, or comorbid medical condition on the association between antidepressant use and AMI. Conclusions Use of antidepressant drugs was not associated with the risk of AMI. ? 2017 Elsevier Ltd |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020826205&doi=10.1016%2fj.jpsychires.2017.06.001&partnerID=40&md5=177eaccdd9714156a633183ec18899ba https://scholars.lib.ntu.edu.tw/handle/123456789/520473 |
ISSN: | 0022-3956 | DOI: | 10.1016/j.jpsychires.2017.06.001 | SDG/關鍵字: | amfebutamone; amitriptyline; citalopram; clomipramine; doxepin; duloxetine; escitalopram; fluoxetine; flupentixol; imipramine; milnacipran; mirtazapine; moclobemide; noradrenalin transporter; paroxetine; serotonin noradrenalin reuptake inhibitor; serotonin transporter; serotonin uptake inhibitor; sertraline; tetracyclic antidepressant agent; trazodone; tricyclic antidepressant agent; venlafaxine; antidepressant agent; acute heart infarction; adult; age; aged; Article; binding affinity; comorbidity; crossover procedure; depression; drug receptor binding; drug use; female; gender; hospitalization; human; major clinical study; male; priority journal; risk assessment; acute disease; chemically induced; heart infarction; hospitalization; middle aged; register; risk; statistics and numerical data; Taiwan; Acute Disease; Adult; Aged; Antidepressive Agents; Female; Hospitalization; Humans; Male; Middle Aged; Myocardial Infarction; Registries; Risk; Taiwan |
顯示於: | 流行病學與預防醫學研究所 |
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