https://scholars.lib.ntu.edu.tw/handle/123456789/520483
標題: | Association between antipsychotic treatment and advanced diabetes complications among schizophrenia patients with type 2 diabetes mellitus | 作者: | CHI-SHIN WU SUSAN SHUR-FEN GAU |
公開日期: | 2016 | 卷: | 42 | 期: | 3 | 起(迄)頁: | 703-711 | 來源出版物: | Schizophrenia Bulletin | 摘要: | Objective: Antipsychotic drug use is an established risk factor for the development of type 2 diabetes mellitus. However, the effect of antipsychotic drug on the progression of diabetes complications remains unclear. This study aimed to explore the association between antipsychotic treatment and advanced diabetes outcome among schizophrenia patients with type 2 diabetes. Methods: The authors conducted a retrospective cohort study using Taiwan's universal health insurance database. A total of 17 629 schizophrenia patients with newly-diagnosed diabetes were enrolled. The mean duration of follow-up, after excluding the first 6-month observation period, was 4.8 years, ranged from 1 month to 11.5 years. Antipsychotic treatment patterns within a 6-month time window were classified into none, irregular use, and regular use. Antipsychotics were further categorized into the high, intermediate, and low metabolic risks. The status of exposure was treated as time-dependent variables. The outcomes measures included any advanced diabetes complications, macrovascular and microvascular complications, and all-cause mortality. Results: Compared to no antipsychotic treatment in the past 6 months, regular antipsychotic use was associated with a lower risk of any advanced diabetes complications (adjusted hazard ratio, aHR = 0.81, 95% CI = 0.69-0.95), macrovascular complications (aHR = 0.80, 95% CI = 0.66-0.97), and all-cause mortality (aHR = 0.73, 95% CI = 0.62-0.85). The hazard ratios for advanced diabetes complications with regular use of antipsychotics with a high, intermediate, and low metabolic risk were 0.69 (95% CI = 0.53-0.91), 0.82 (95% CI = 0.68-0.99), and 0.85 (95% CI = 0.70-1.02), respectively. Conclusions: Regular antipsychotic treatment in the past 6 months was associated with reduced risks of any diabetes complications, compared to no antipsychotic treatment. ? The Author 2015. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84966455375&doi=10.1093%2fschbul%2fsbv187&partnerID=40&md5=4f3e2f3401a604557c19e810780c0982 https://scholars.lib.ntu.edu.tw/handle/123456789/520483 |
ISSN: | 0586-7614 | DOI: | 10.1093/schbul/sbv187 | SDG/關鍵字: | benzodiazepine; neuroleptic agent; oral antidiabetic agent; neuroleptic agent; acute heart infarction; adult; Article; cerebrovascular accident; cohort analysis; controlled study; data base; diabetic foot; diabetic nephropathy; diabetic retinopathy; drug exposure; female; follow up; human; major clinical study; male; middle aged; mortality; non insulin dependent diabetes mellitus; outcome assessment; peripheral vascular disease; priority journal; retrospective study; schizophrenia; adolescent; aged; chemically induced; comorbidity; complication; Diabetes Complications; Diabetes Mellitus, Type 2; schizophrenia; statistics and numerical data; Taiwan; young adult; Adolescent; Adult; Aged; Antipsychotic Agents; Comorbidity; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Humans; Male; Middle Aged; Outcome Assessment (Health Care); Schizophrenia; Taiwan; Young Adult |
顯示於: | 流行病學與預防醫學研究所 |
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