https://scholars.lib.ntu.edu.tw/handle/123456789/520620
標題: | TRPV4 promotes acoustic wave-mediated BBB opening via Ca2+/PKC-δ pathway | 作者: | Liao, Wei-Hao MING-YEN HSIAO Kung, Yi HAO-LI LIU Béra, Jean-Christophe Inserra, Claude WEN-SHIANG CHEN |
關鍵字: | Acoustic waves; Blood–brain barrier; PKC-δ; Shockwave; TRPV4; Ultrasound | 公開日期: | 十一月-2020 | 出版社: | ELSEVIER | 卷: | 26 | 起(迄)頁: | 15 | 來源出版物: | Journal of advanced research | 摘要: | Numerous studies have shown the ability of low-energy acoustic waves such as focused ultrasound or shockwave to transiently open blood-brain barrier (BBB) and facilitate drug delivery to the brain. Preclinical and clinical evidences have well demonstrated the efficacy and safety in treating various brain disorders. However, the molecular mechanisms of acoustic waves on the BBB are still not fully understood. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/520620 | ISSN: | 2090-1232 | DOI: | 10.1016/j.jare.2020.06.012 |
顯示於: | 醫學系 |
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