|Title:||Effects of protein supplementation combined with exercise training on muscle mass and function in older adults with lower-extremity osteoarthritis: A systematic review and meta-analysis of randomized trials||Authors:||Liao C.-D.
|Issue Date:||2020||Publisher:||MDPI AG||Journal Volume:||12||Journal Issue:||8||Start page/Pages:||1ค๋19ค้||Source:||Nutrients||Abstract:||
Aging and osteoarthritis (OA) are associated with a high risk of muscle mass loss, which can lead to physical disability. This study investigated the effectiveness of protein supplementation combined with exercise training (PS + ET) in improving muscle mass and functional outcomes in older adults with lower-limb OA. A comprehensive search of online databases was performed to identify randomized controlled trials (RCTs) on the effectiveness of PS + ET in older adults with hip or knee OA. Meta-analysis and risk of bias assessment of the included RCTs were conducted. Six RCTs were included in this systemic review; they had a median (range/total) Physiotherapy Evidence Database (PEDro) score of 7 (6–9) out of 10, respectively. Five RCTs that enrolled patients who underwent total joint replacement were included in this meta-analysis. The PS + ET group exhibited significant improvements in muscle mass (standard mean difference [SMD] = 1.13, p < 0.00001), pain (SMD = 1.36, p < 0.00001), and muscle strength (SMD = 0.44, p = 0.04). Our findings suggest that PS + ET improves muscle mass, muscle strength, and functional outcomes and reduces pain in older adults with lower-limb OA, particularly in those who have undergone total joint replacement. ? 2020 by the authors. Licensee MDPI, Basel, Switzerland.
|ISSN:||2072-6643||DOI:||10.3390/nu12082422||metadata.dc.subject.other:||C reactive protein; interleukin 6; tumor necrosis factor; body mass; chair rise performance; diet supplementation; exercise; exercise intensity; follow up; Harris hip score; hospital discharge; human; Knee Injury and Osteoarthritis Outcome Score; meta analysis; muscle function; muscle mass; muscle strength; myalgia; obesity; osteoarthritis; outcome assessment; pain assessment; patient-reported outcome; physical activity; physical mobility; physiotherapy; protein diet; randomized controlled trial (topic); resistance training; Review; sarcopenia; Short Form 36; six minute walk test; stair climbing; systematic review; timed up and go test; total arthroplasty; total hip replacement; treatment outcome; walking speed; administration and dosage; aged; complication; dietary supplement; drug effect; exercise; female; kinesiotherapy; male; muscle atrophy; osteoarthritis; pathophysiology; physiology; procedures; protein intake; very elderly; Aged; Aged, 80 and over; Dietary Proteins; Dietary Supplements; Exercise; Exercise Therapy; Female; Humans; Male; Muscle Strength; Muscular Atrophy; Osteoarthritis; Physical Functional Performance; Randomized Controlled Trials as Topic; Treatment Outcome
|Appears in Collections:||醫學院附設醫院 (臺大醫院)|
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