https://scholars.lib.ntu.edu.tw/handle/123456789/521048
標題: | Detection of susceptibility loci on APOA5 and COLEC12 associated with metabolic syndrome using a genome-wide association study in a Taiwanese population | 作者: | Lin E. PO-HSIU KUO Liu Y.-L. Yang A.C. HSIU-PO KUO |
公開日期: | 2017 | 出版社: | Impact Journals LLC | 卷: | 8 | 期: | 55 | 起(迄)頁: | 93349-93359 | 來源出版物: | Oncotarget | 摘要: | Background: Although the association of single nucleotide polymorphisms (SNPs) with metabolic syndrome (MetS) has been reported in various populations in several genome-wide association studies (GWAS), the data is not conclusive. In this GWAS study, we assessed whether SNPs are associated with MetS and its individual components independently and/or through complex interactions in a Taiwanese population. Methods: A total of 10,300 Taiwanese subjects were assessed in this study. Metabolic traits such as waist circumference, triglyceride, high-density lipoprotein (HDL) cholesterol, systolic and diastolic blood pressure, and fasting glucose were measured. Results: Our data showed an association of MetS at the genome-wide significance level (P < 8.6 x 10-8) with two SNPs, including the rs662799 SNP in the apolipoprotein A5 (APOA5) gene and the rs16944558 SNP in the collectin subfamily member 12 (COLEC12) gene. Moreover, we identified the effect of APOA5 rs662799 on triglyceride and HDL, the effect of rs1106475 in the actin filament associated protein 1 like 2 (AFAP1L2) gene on systolic blood pressure, and the effect of rs17667932 in the mediator complex subunit 30 (MED30) gene on fasting glucose. Additionally, we found that an interaction between the APOA5 rs662799 and COLEC12 rs16944558 SNPs influenced MetS, high triglyceride, and low HDL. Conclusions: Our study indicates that the APOA5 and COLEC12 genes may contribute to the risk of MetS and its individual components independently as well as through gene-gene interactions. ? Lin et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032990465&doi=10.18632%2foncotarget.20967&partnerID=40&md5=163b0842fb9d45fd72e80437e488000c https://scholars.lib.ntu.edu.tw/handle/123456789/521048 |
ISSN: | 1949-2553 | DOI: | 10.18632/oncotarget.20967 | SDG/關鍵字: | glucose; high density lipoprotein cholesterol; triacylglycerol; adult; APOA5 gene; Article; biological trait; cholesterol blood level; COLEC12 gene; controlled study; diastolic blood pressure; disease association; female; gene; gene function; gene identification; gene interaction; gene locus; genome-wide association study; glucose blood level; human; major clinical study; male; MED30 gene; metabolic syndrome X; metabolic trait; middle aged; single nucleotide polymorphism; systolic blood pressure; Taiwanese; triacylglycerol blood level; waist circumference |
顯示於: | 流行病學與預防醫學研究所 |
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