https://scholars.lib.ntu.edu.tw/handle/123456789/521596
標題: | Zinc, copper, and superoxide dismutase in hepatocellular carcinoma | 作者: | Liaw K.-Y. PO-HUANG LEE Wu F.-C. Tsai J.-S. Lin-Shiau S.-Y. |
公開日期: | 1997 | 卷: | 92 | 期: | 12 SUPPL. | 起(迄)頁: | 2260-2263 | 來源出版物: | American Journal of Gastroenterology | 摘要: | Superoxide dismutase (Cu/Zn), a metalloenzyme, activity was found to be significantly lower in the human hepatocellular carcinoma (hepatoma tissue) (0.78 ± 0.33 U/μg protein) compared with that seen in the surrounding "normal" or cirrhotic tissue (1.40 ± 0.48 U/μg; 1.27 ± 0.64 U/μg). The SOD activity of "normal" appearing liver cells adjacent to the tumor or cirrhotic tissue is still lower than that level observed in the normal liver from the subjects without known liver disease (1.40 ± 0.48 U/μg vs 2.94 ± 1.53 U/μg). We have also observed that the trace elements of zinc and copper, which are essential in expressing the enzyme activity are also significantly lower in the hepatoma (22.54 ± 6.73 μg and 2.83 ± 1.16 μg per gram of tissue) compared with those in the surrounding "normal" hepatic tissue (Zn2+, 64.36 ± 9.17 μg/g; Cu2+, 11.43 ± 4.74 μg/g). The difference in the zinc content between the "normal" and the cirrhotic tissue is also significant (64.36 ± 9.17 μg/g vs 42.37 ± 10.97 μg/g). However, the copper content in the cirrhotic tissue is higher but not statistically different from that level in the "normal" tissue (15.53 ± 5.90 μg/g vs 11.43 ± 4.74 μg/g). Furthermore, the plasma zinc level is significantly lower among the patients who have suffered from hepatoma compared with those subjects without known liver disease (631.73 ± 52.43 μg/L vs 845.53 ± 68.13 μg/L). Our data suggest that the superoxide dismutase activity is impaired in the hepatoma tissue. The lower concentration of trace elements (Zn2+ and Cu2+) found in the hepatoma tissue may contribute to cause the difference in the observed enzymic activities. Copyright ? 1997 by Am. Coll. of Gastroenterology. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030777595&partnerID=40&md5=dc21d10f87fdbf1769cd67f7a637abba https://scholars.lib.ntu.edu.tw/handle/123456789/521596 |
ISSN: | 0002-9270 | SDG/關鍵字: | copper; superoxide dismutase; trace element; zinc; adult; aged; article; controlled study; enzyme activity; female; human; human tissue; liver cell carcinoma; major clinical study; male; priority journal; Adult; Aged; Carcinoma, Hepatocellular; Copper; Female; Humans; Liver; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Mitochondria, Liver; Proteins; Superoxide Dismutase; Trace Elements; Zinc |
顯示於: | 醫學系 |
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