https://scholars.lib.ntu.edu.tw/handle/123456789/521753
標題: | Assessing effects of disease genes and gene-environment interactions: The case-spouse design and the counterfactual-control analysis | 作者: | WEN-CHUNG LEE Chang C.-H. |
公開日期: | 2006 | 卷: | 60 | 期: | 8 | 起(迄)頁: | 683-685 | 來源出版物: | Journal of Epidemiology and Community Health | 摘要: | Background: Assessing joint genetic and environmental contributions to disease risk is the central issue in many genetic epidemiological studies. To characterise the effects of a gene, the case-control study may suffer from fne problem of population stratification bias. For a late onset disease, recruiting control subjects into case-parents and case-sibling studies may be difficult. Methods: Two novel approaches to analysing case-spouse data are introduced: the 1:1 case-counterfactual-control analysis (genotype swapping between the case and their spouse) and the 1:5 case-counterfactual-controls analysis (allele swapping). Results: Both can be implemented using statistical packages that allow matched analysis (the conditional logistic regression) to yield valid estimates of the genotype relative risk, the gene-environment interaction parameter, the gene-sex interaction parameter, and the gene-environment-sex three factor interaction parameter (if desired), if certain assumptions are fulfilled. Conclusion: Because of the ease in recruiting subjects, and in collecting and analysing data, this approach makes a convenient tool for gene characterisation. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33746349521&doi=10.1136%2fjech.2005.043554&partnerID=40&md5=fa4e5773d2657988903aeb16f15e7deb https://scholars.lib.ntu.edu.tw/handle/123456789/521753 |
ISSN: | 0143-005X | DOI: | 10.1136/jech.2005.043554 | SDG/關鍵字: | disease; gene; health risk; intersexual interaction; regression analysis; risk assessment; risk factor; allele; article; case control study; controlled study; environmental factor; female; gene interaction; genetic epidemiology; genotype; heredity; human; intermethod comparison; logistic regression analysis; male; parent; risk factor; sexual behavior; sibling; spouse; statistical analysis; stratification |
顯示於: | 流行病學與預防醫學研究所 |
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