https://scholars.lib.ntu.edu.tw/handle/123456789/521795
標題: | Estimating genotype relative risks in case-parental control studies: An optimal weighting approach | 作者: | WEN-CHUNG LEE Chang C.-H. |
公開日期: | 2000 | 卷: | 152 | 期: | 5 | 起(迄)頁: | 487-492 | 來源出版物: | American Journal of Epidemiology | 摘要: | The 'case-parental control study' is a novel study design. It can quantify the relations between candidate genes and disease risk. Previous authors have proposed noniterative methods for estimating 'genotype relative risks' (GRRs) in case-parental control studies. Here the authors propose yet another noniterative method. The new method is simple. It involves taking certain weighted averages with weights chosen according to one's educated guess about the likely values of the true GRRs. Monte Carlo simulation shows that the new estimators are approximately unbiased and that they have smaller variances than the previous estimators. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034282868&doi=10.1093%2faje%2f152.5.487&partnerID=40&md5=f303bd2097f38d6c082073f74e21fec2 https://scholars.lib.ntu.edu.tw/handle/123456789/521795 |
ISSN: | 0002-9262 | DOI: | 10.1093/aje/152.5.487 | SDG/關鍵字: | gene dosage; gene frequency; gene locus; genetic susceptibility; genotype; human; intermethod comparison; marker gene; review; risk factor; system analysis; Adult; Case-Control Studies; Child; Epidemiologic Methods; Genetic Predisposition to Disease; Genotype; Humans; Monte Carlo Method; Risk Assessment |
顯示於: | 流行病學與預防醫學研究所 |
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