|Title:||Copy number variant hotspots in Han Taiwanese population induced pluripotent stem cell lines - lessons from establishing the Taiwan human disease iPSC Consortium Bank||Authors:||Huang, Ching-Ying
Nicholson, Martin W
Yen, B Lin Ju
Kamp, Timothy J
Wu, Joseph C
Hsieh, Patrick C H
|Keywords:||Cell differentiation; Copy number variant; Drug screening; Hotspot; Human induced pluripotent stem cell; Stem cell bank||Issue Date:||4-Sep-2020||Publisher:||BMC||Journal Volume:||27||Journal Issue:||1||Source:||Journal of biomedical science||Abstract:||
The Taiwan Human Disease iPSC Service Consortium was established to accelerate Taiwan's growing stem cell research initiatives and provide a platform for researchers interested in utilizing induced pluripotent stem cell (iPSC) technology. The consortium has generated and characterized 83 iPSC lines: 11 normal and 72 disease iPSC lines covering 21 different diseases, several of which are of high incidence in Taiwan. Whether there are any reprogramming-induced recurrent copy number variant (CNV) hotspots in iPSCs is still largely unknown.
|Appears in Collections:||基因體暨蛋白體醫學研究所|
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