https://scholars.lib.ntu.edu.tw/handle/123456789/522346
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Kuo L.-C. | en_US |
dc.contributor.author | Song Y.-Q. | en_US |
dc.contributor.author | CHIEN-AN YAO | en_US |
dc.contributor.author | Cheng I.H. | en_US |
dc.contributor.author | Chien C.-T. | en_US |
dc.contributor.author | Lee G.-C. | en_US |
dc.contributor.author | Yang W.-C. | en_US |
dc.contributor.author | Lin Y. | en_US |
dc.creator | Kuo L.-C.;Song Y.-Q.;Chien-An Yao;Cheng I.H.;Chien C.-T.;Lee G.-C.;Yang W.-C.;Lin Y. | - |
dc.date.accessioned | 2020-11-27T03:25:51Z | - |
dc.date.available | 2020-11-27T03:25:51Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0021-8561 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059366147&doi=10.1021%2facs.jafc.8b04514&partnerID=40&md5=3de146b78ec64de6d6d581cdb0a11a1a | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/522346 | - |
dc.description.abstract | Utilizing the N-methyl-d-aspartate (NMDA) receptor antagonist as a strategy, memantine is the only agent available for clinically treating mild to severe Alzheimer's disease (AD). Our aim was to develop novel similar herb-based drugs. Using a screening platform, ginkgolide A (GA), a pure compound extracted from Ginkgo biloba, was found to attenuate amyloid β (Aβ)-induced abnormal depolarization in mouse primary cortical neurons. Using receptor agonists, it was determined that GA inhibits both NMDA receptors and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. Furthermore, the Aβ-induced increase in c-Jun N-terminal kinase phosphorylation in neurons was prevented by GA. Body weight, glutamate oxaloacetate transaminase, glutamic-pyruvic transaminase, liver histology, and kidney histology were similar when the wild-type/AD animal model mice with and without GA treatment were compared. This pure compound improves the memory of wild-type mice. Our findings indicate that GA has great potential clinically for the treatment of AD because it might target NMDA receptors just like memantine. ? 2018 American Chemical Society. | - |
dc.publisher | American Chemical Society | - |
dc.relation.ispartof | Journal of Agricultural and Food Chemistry | - |
dc.subject | Alzheimer's disease; amyloid β; ginkgolide A; glutamate receptors; herbal medicines; memantine | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Depolarization; Diagnosis; Glycoproteins; Histology; Mammals; Neurons; Alzheimer's disease; Ginkgolide A; Glutamate receptor; Herbal medicines; Memantine; Neurodegenerative diseases; amyloid beta protein; Ginkgo biloba extract; ginkgolide; ginkgolide A; lactone; n methyl dextro aspartic acid receptor; neuroprotective agent; plant extract; Alzheimer disease; animal; brain cortex; C57BL mouse; chemistry; cytology; drug effect; genetics; Ginkgo biloba; human; male; metabolism; mouse; nerve cell; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Ginkgo biloba; Ginkgolides; Humans; Lactones; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Plant Extracts; Receptors, N-Methyl-D-Aspartate | - |
dc.title | Ginkgolide A Prevents the Amyloid-β-Induced Depolarization of Cortical Neurons | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1021/acs.jafc.8b04514 | - |
dc.identifier.pmid | 30541279 | - |
dc.identifier.scopus | 2-s2.0-85059366147 | - |
dc.relation.pages | 81-89 | - |
dc.relation.journalvolume | 67 | - |
dc.relation.journalissue | 1 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
crisitem.author.dept | Family Medicine | - |
crisitem.author.dept | Family Medicine-NTUH | - |
crisitem.author.orcid | 0000-0001-8074-6379 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。