https://scholars.lib.ntu.edu.tw/handle/123456789/522643
標題: | Post-coital vaginal douching is risky for non-regression of low-grade squamous intraepithelial lesion of the cervix | 作者: | Chu T.-Y. Hsiung C.A. CHI-AN CHEN Chou H.-H. Ho C.-M. Chien T.-Y. Chang H.-J. Chou C.-Y. Liou J.-D. Kan Y.-Y. CHANG-YAO HSIEH |
公開日期: | 2011 | 卷: | 120 | 期: | 3 | 起(迄)頁: | 449-453 | 來源出版物: | Gynecologic Oncology | 摘要: | Background: Vaginal douching is a common practice worldwide. Its effect on the natural history of the early lesion of human papillomavirus (HPV) infection, low-grade squamous intraepithelial lesion (LSIL), is unknown. Methods: In a prospective nation-wide cohort (n = 1332), epidemiological variables including habit of vaginal douching after intercourse and outcomes of LSIL were studied. Colposcopy-confirmed LSIL women (n = 295) were followed every 3 months. Parameters of HPV infection, sexual behavior, personal hygiene and environmental exposures were compared with the follow-up outcomes. Results: There was a 15% chance of HSIL co-existing with the LSIL cytology result. Eight percent of colposcopy-confirmed LSIL were found with HSIL in 1 year. With a follow-up of up to 36 months, 83% LSIL regressed, 11% progressed and 6% persisted. The mean time (95% CIs) to regression and progression were 5.2 (4.7-5.8) and 8.0 (5.8-10.3) months, respectively. Risk factors of the non-regression of LSIL included HPV prevalence on enrollment, habit of vaginal douching after intercourse with a hygiene product and non-regular Pap screening, with odd ratio of 4.4 (1.9-10.3), 3.14 (1.04-9.49) and 2.12 (1.24-3.62), respectively. HPV prevalence and vaginal douching also conferred a slower regression of LSIL (8.0 vs. 4.1 months, P < .001 and 8.0 vs. 5.6 months, P = 0.02, respectively). Conclusion: The study disclosed a transient but warning nature of cytological LSIL. Practicing of vaginal douching after intercourse, especially with hygiene products, is associated with non-regression of LSIL. ? 2010 Elsevier Inc. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79951577440&doi=10.1016%2fj.ygyno.2010.11.006&partnerID=40&md5=1232807a216e31d8a88900cf1f8dd0b9 https://scholars.lib.ntu.edu.tw/handle/123456789/522643 |
ISSN: | 0090-8258 | DOI: | 10.1016/j.ygyno.2010.11.006 | SDG/關鍵字: | adult; article; colposcopy; controlled study; cytology; environmental exposure; female; high grade squamous intraepithelial lesion; human; low grade squamous intraepithelial lesion; major clinical study; Papanicolaou test; papillomavirus infection; personal hygiene; postcoital test; priority journal; prospective study; risk factor; sexual behavior; sexual intercourse; uterine cervix disease; vaginal lavage; Adult; Carcinoma, Squamous Cell; Cervical Intraepithelial Neoplasia; Cohort Studies; Coitus; Colposcopy; Cross-Sectional Studies; Female; Humans; Papillomaviridae; Prospective Studies; Risk Factors; Therapeutic Irrigation; Uterine Cervical Neoplasms |
顯示於: | 醫學系 |
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