https://scholars.lib.ntu.edu.tw/handle/123456789/522675
標題: | Seroprevalence of human papillomaviruses and Chlamydia trachomatis and cervical cancer risk: Nested case-control study | 作者: | Naucler P. Chen H.-C. Persson K. You S.-L. CHANG-YAO HSIEH Sun C.-A. Dillner J. Chen C.-J. |
公開日期: | 2007 | 卷: | 88 | 期: | 3 | 起(迄)頁: | 814-822 | 來源出版物: | Journal of General Virology | 摘要: | A nested case-control study of invasive and in situ cervical cancer was performed within a community-based cohort of 13 595 Taiwanese women assembled in 1991, with a follow-up period of 9 years. Baseline serum or plasma samples were analysed for antibodies against human papillomavirus (HPV) types 6, 16 and 18 and Chlamydia trachomatis. In total, 114 cases (42 incident cases identified during follow-up and 72 prevalent cases identified at baseline) and 519 matched controls were included in the study. HPV-16 seropositivity was strongly associated with cervical cancer (OR=6.33; 95 % Cl 3.45-11.62). Overall, C. trachomatis was not associated with cervical cancer, but was associated with cervical cancer in analyses restricted to incident cases of cancer (OR=2.94; 95 % Cl 1.17-7.42) or to cases in which serum samples were analysed (OR=3.13; 95 % Cl 1.16-8.47). An antagonistic interaction between HPV-6 and -16 was found in a multiplicative model. These results suggest that different HPV types might interfere in cervical carcinogenesis and that C. trachomatis is associated with cervical cancer in prospective studies, and support the notion that HPV-16 seropositivity is strongly associated with cervical cancer. ? 2007 SGM. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33847644663&doi=10.1099%2fvir.0.82503-0&partnerID=40&md5=d52d897d54517d6c8932768928061967 https://scholars.lib.ntu.edu.tw/handle/123456789/522675 |
ISSN: | 0022-1317 | DOI: | 10.1099/vir.0.82503-0 | SDG/關鍵字: | immunoglobulin G; antibody response; article; bacterial infection; blood sampling; cancer incidence; cancer risk; carcinogenesis; carcinoma in situ; case control study; Chlamydia trachomatis; cohort analysis; condyloma; controlled study; female; follow up; genetic association; human; Human papillomavirus type 16; Human papillomavirus type 18; Human papillomavirus type 6; incidental finding; invasive carcinoma; major clinical study; priority journal; risk assessment; seroprevalence; Taiwan; uterine cervix cancer; Adult; Antibodies, Bacterial; Antibodies, Viral; Case-Control Studies; Chlamydia Infections; Chlamydia trachomatis; Female; Human papillomavirus 16; Human papillomavirus 18; Human papillomavirus 6; Humans; Middle Aged; Papillomavirus Infections; Risk Factors; Seroepidemiologic Studies; Statistics; Taiwan; Uterine Cervical Neoplasms; Chlamydia trachomatis; Human papillomavirus; Human papillomavirus type 16; Human papillomavirus types; Papillomaviridae |
顯示於: | 醫學系 |
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