https://scholars.lib.ntu.edu.tw/handle/123456789/523149
標題: | Influence of Non-Alcoholic Fatty Liver Disease on Autonomic Changes Evaluated by the Time Domain, Frequency Domain, and Symbolic Dynamics of Heart Rate Variability | 作者: | Liu Y.-C. CHI-SHENG HUNG YEN-WEN WU Lee Y.-C. YEN-HUNG LIN Lin C. Lo M.-T. Chan C.-C. Ma H.-P. YI-LWUN HO CHIEN-HUNG CHEN |
公開日期: | 2013 | 卷: | 8 | 期: | 4 | 來源出版物: | PLoS ONE | 摘要: | Background:Non-alcoholic fatty liver disease (NAFLD) is associated with cardiovascular atherosclerosis independent of classical risk factors. This study investigated the influence of NAFLD on autonomic changes, which is currently unknown.Methods:Subjects without an overt history of cardiovascular disease were enrolled during health checkups. The subjects diagnosed for NAFLD using ultrasonography underwent 5-min heart rate variability (HRV) measurements that was analyzed using the following indices: (1) the time domain with the standard deviation of N-N (SDNN) intervals and root mean square of successive differences between adjacent N-N intervals (rMSSD); (2) the frequency domain with low frequency (LF) and high frequency (HF) components; and (3) symbolic dynamics analysis. Routine blood biochemistry data and serum leptin levels were analyzed. Homeostasis model assessment of insulin resistance (HOMA-IR) was measured.Results:Of the 497 subjects (mean age, 46.2 years), 176 (35.4%) had NAFLD. The HRV indices (Ln SDNN, Ln rMSSD, Ln LF, and Ln HF) were significantly decreased in the NAFLD group (3.51 vs 3.62 ms, 3.06 vs 3.22 ms, 5.26 vs 5.49 ms2, 4.49 vs 5.21 ms2, respectively, all P<0.05). Ln SDNN was significantly lower in the NAFLD group after adjustment for age, sex, hypertension, dyslipidemia, metabolic syndrome, body mass index, smoking, estimated glomerular filtration rate, HOMA-IR, and leptin (P<0.05). In the symbolic dynamic analysis, 0 V percentage was significantly higher in the NAFLD group (33.8% vs 28.7%, P = 0.001) and significantly correlated with linear HRV indices (Ln SDNN, Ln rMSSD, and Ln HF).Conclusions:NAFLD is associated with decreased Ln SDNN and increased 0 V percentage. The former association was independent of conventional cardiovascular risk factors and serum biomarkers (insulin resistance and leptin). Further risk stratification of autonomic dysfunction with falls or cardiovascular diseases by these HRV parameters is required in patients with NAFLD. ? 2013 Liu et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84876522098&doi=10.1371%2fjournal.pone.0061803&partnerID=40&md5=83fd4dee41c5d4980fd313c8b2a94ea2 https://scholars.lib.ntu.edu.tw/handle/123456789/523149 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0061803 | SDG/關鍵字: | alanine aminotransferase; aspartate aminotransferase; beta adrenergic receptor blocking agent; cholesterol; creatinine; gamma glutamyltransferase; glucose; high density lipoprotein cholesterol; insulin; leptin; lipid; low density lipoprotein cholesterol; leptin; adult; age; aged; article; autonomic dysfunction; blood analysis; blood level; body mass; cardiovascular risk; controlled study; correlation analysis; diastolic blood pressure; diet restriction; disease association; dyslipidemia; echography; female; glomerulus filtration rate; heart rate; heart rate variability; Holter monitoring; human; hypertension; insulin blood level; insulin resistance; major clinical study; male; metabolic syndrome X; nonalcoholic fatty liver; risk factor; sex difference; smoking; systolic blood pressure; time; waist circumference; atherosclerosis; blood; complication; diabetes mellitus; fatty liver; heart rate; hypertension; middle aged; nonalcoholic fatty liver; pathophysiology; Adult; Age Factors; Atherosclerosis; Body Mass Index; Diabetes Mellitus; Fatty Liver; Female; Glomerular Filtration Rate; Heart Rate; Humans; Hypertension; Insulin Resistance; Leptin; Male; Metabolic Syndrome X; Middle Aged; Non-alcoholic Fatty Liver Disease; Risk Factors; Sex Factors |
顯示於: | 醫學系 |
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