https://scholars.lib.ntu.edu.tw/handle/123456789/523177
標題: | Clinical manifestations and survival of patients with hepatocellular carcinoma and cardiac metastasis | 作者: | Liu Y.-C. YI-LWUN HO GUAN-TARN HUANG DING-SHINN CHEN JIN-CHUAN SHEU CHIEN-HUNG CHEN |
公開日期: | 2010 | 出版社: | Blackwell Publishing | 卷: | 25 | 期: | 1 | 起(迄)頁: | 150-155 | 來源出版物: | Journal of Gastroenterology and Hepatology (Australia) | 摘要: | Background and Aim: Antemortem diagnosis of hepatocellular carcinoma (HCC) with cardiac metastasis is uncommon. To clarify the clinical manifestation and survival of HCC patients with cardiac metastases, we initiated the present study. Methods: We retrospectively analyzed 48 HCC patients with metastases into cardiac cavity diagnosed antemortem. The baseline clinical characteristics, echocardiogram, treatment modality and the outcome data were collected. Results: The most common symptoms of cardiac metastasis included asymptomatic in 19 cases (39.5%), bilateral lower leg edema in 18 cases (37.5%) and exertional dyspnea in 15 cases (31.3%). The median and mean survival times from the time of diagnosis of cardiac metastasis were 102 days and 161 days, respectively. Compared with another cohort of 48 patients with age-, gender-, and stage-matched HCC patients without cardiac metastasis, the median survival in the cardiac metastasis group was similar to the control group (68 days) (P = 0.67). The cause of death was HCC in 29, hepatic failure in seven, multiple organ failure in four, gastrointestinal bleeding in three, sepsis in two, pulmonary embolism in one, respiratory failure in one, and acute myocardial infarction in one. Conclusions: Hepatocellular carcinoma patients with cardiac metastases were in the advanced stages. These patients had limited survival from the diagnosis of cardiac metastases. The most common cause of death was related to HCC per se or the underlying liver disease. Only a few patients expired because of cardiac metastases. ? 2009 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-73449115699&doi=10.1111%2fj.1440-1746.2009.06036.x&partnerID=40&md5=5907c63afa970a2a64ad23224239cb34 https://scholars.lib.ntu.edu.tw/handle/123456789/523177 |
ISSN: | 0815-9319 | DOI: | 10.1111/j.1440-1746.2009.06036.x | SDG/關鍵字: | antineoplastic agent; acute heart infarction; adult; age distribution; article; cancer staging; cancer survival; cause of death; chemoembolization; clinical article; clinical feature; controlled study; dyspnea; echocardiography; female; gastrointestinal hemorrhage; heart infarction; heart metastasis; histopathology; human; human tissue; leg edema; liver cell carcinoma; liver failure; lung embolism; male; multiple organ failure; priority journal; respiratory failure; sepsis; sex difference |
顯示於: | 醫學系 |
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