https://scholars.lib.ntu.edu.tw/handle/123456789/523465
標題: | The prevalence of expression of MAGE-A3 and PRAME tumor antigens in East and South East Asian non-small cell lung cancer patients | 作者: | Thongprasert S. PAN-CHYR YANG Lee J.S. Soo R. Gruselle O. Myo A. Louahed J. Lehmann F.F. Brichard V.G. Coche T. |
關鍵字: | Antigen-specific cancer immunotherapy; MAGE-A3 antigen; Non-small cell lung cancer; PRAME antigen; Tumor-associated antigens | 公開日期: | 2016 | 出版社: | Elsevier Ireland Ltd | 卷: | 101 | 起(迄)頁: | 137-144 | 來源出版物: | Lung Cancer | 摘要: | Introduction Treatment of non-small cell lung cancer (NSCLC) is an important and often unmet medical need regardless of the disease stage at the time of first diagnosis. Antigen-specific immunotherapy may be a feasible therapeutic option if tumor associated antigens (TAAs) that can be targeted by the patient's immune system are identified. The study objective (NCT01837511) was to investigate the expression rates of MAGE-A3 and PRAME in tumors from East Asian NSCLC patients, and the associations between TAA expression and clinico-pathologic patient characteristics. Methods Archived formalin-fixed paraffin-embedded tumor tissue specimens were tested for MAGE-A3 and PRAME expression by quantitative reverse transcription polymerase chain reaction. Exploratory analyses of the impact of patient and tumor characteristics on antigen expression were performed by multivariate logistic regression analyses. Results A total of 377 specimens were tested and a valid expression result was obtained for 86.5% and 92.6% for MAGE-A3 and PRAME, respectively. Of the specimens with valid test results, 26.4% expressed MAGE-A3, 49.9% PRAME, 20.0% both and 57.5% expressed at least one TAA. The same pattern of associations between antigen expression and patient and tumor characteristics was found for both TAAs: higher rates of antigen-positive tumors were found in squamous cell carcinomas compared to adenocarcinomas, and for smokers compared to non-smokers. Conclusions Expression of MAGE-A3 and PRAME suggests an association with tumor histology and the patient's smoking status. The rates of TAA-positive tumors found in these East and South East Asian NSCLC patients indicate that both antigens may serve as targets for antigen-specific immunotherapies. ? 2016 The Authors |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84991710658&doi=10.1016%2fj.lungcan.2016.09.006&partnerID=40&md5=2fe2aa61a3b62b71a2e9bc638278f6f4 https://scholars.lib.ntu.edu.tw/handle/123456789/523465 |
ISSN: | 0169-5002 | DOI: | 10.1016/j.lungcan.2016.09.006 | SDG/關鍵字: | melanoma antigen 3; preferentially expressed antigen of melanoma antigen; tumor antigen; unclassified drug; MAGEA3 protein, human; PRAME protein, human; tumor antigen; tumor marker; tumor protein; adult; aged; antigen expression; Article; cancer patient; disease association; East Asian; female; gene; gene expression; histology; human; human tissue; lung adenocarcinoma; MAGE A3 gene; major clinical study; male; middle aged; non small cell lung cancer; observational study; PRAME gene; priority journal; retrospective study; reverse transcription polymerase chain reaction; sex difference; smoking; Southeast Asian; squamous cell lung carcinoma; tumor volume; adenocarcinoma; cancer staging; clinical trial; epidemiology; Far East; gene expression regulation; immunotherapy; lung tumor; metabolism; multicenter study; non small cell lung cancer; pathology; prevalence; procedures; Southeast Asia; squamous cell carcinoma; very elderly; Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antigens, Neoplasm; Asia, Southeastern; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Far East; Female; Gene Expression Regulation, Neoplastic; Humans; Immunotherapy; Lung Neoplasms; Male; Middle Aged; Neoplasm Proteins; Neoplasm Staging; Prevalence; Retrospective Studies; Smoking |
顯示於: | 醫學系 |
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