https://scholars.lib.ntu.edu.tw/handle/123456789/523530
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Ccheng S.-L. | en_US |
dc.contributor.author | Su K.-C. | en_US |
dc.contributor.author | HAO-CHIEN WANG | en_US |
dc.contributor.author | Perng D.-W. | en_US |
dc.contributor.author | PAN-CHYR YANG | en_US |
dc.creator | Ccheng S.-L.;Su K.-C.;Wang H.-C.;Perng D.-W.;Pan-Chyr Yang | - |
dc.date.accessioned | 2020-12-02T02:33:40Z | - |
dc.date.available | 2020-12-02T02:33:40Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1177-8881 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84901663502&doi=10.2147%2fDDDT.S63100&partnerID=40&md5=809556e8d6262aa29cab92d493763ec3 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/523530 | - |
dc.description.abstract | Purpose: Complications of pneumonia development in patients with chronic obstructive pulmonary disease (COPD) receiving inhaled corticosteroid (ICS) therapy have been documented. the aim of this study was to focus on clinical efficacy and the incidence of pneumonia between COPD patients receiving medium and high doses of ICS. patients and methods: This prospective, Randomized study included COPD patients identified from three tertiary medical centers from 2010 to 2012. the patients were randomized into two groups: high dose (HD; Fluticasone 1,000 μg + salmeterol 100 μg/day) and medium dose (MD; fluticasone 500 μg + salmeterol 100 μg/day). Lung function with forced expiratory volume in 1 second (FEV1), forced vital capacity, and COPD-assessment test (CAT) were checked every 2 months. The frequency of acute exacerbations and number of pneumonia events were measured. The duration of the study period was 1 year. Results: In total, 237 COPD patients were randomized into the two treatment arms (115 in the HD group, 122 in the MD group). The FEV1 level was significantly improved in the patients in the HD group compared with those in the MD group (HD 103.9±26.6 mL versus MD 51.4±19.7 mL, P,0.01) at the end of the study. CAT scores were markedly improved in patients using an HD compared to those using an MD (HD 13±5 versus MD 16±7, P=0.05). There was a significant difference in the percentage of annual rates in acute exacerbations (HD 0.16 versus MD 0.34, P,0.01) between the two groups. The incidence of pneumonia was similar in the two groups (HD 0.08 versus MD 0.10, P=0.38). Conclusion: COPD patients treated with high doses of ICS had more treatment benefits and no significant increases in the incidence in pneumonia. Higher-dose ICS treatment may be suitable for COPD therapy. ? 2014 Cheng et al. | - |
dc.publisher | Dove Medical Press Ltd. | - |
dc.relation.ispartof | Drug Design, Development and Therapy | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | fluticasone; salmeterol; corticosteroid; adverse outcome; aged; article; chronic obstructive lung disease; chronic obstructive pulmonary disease assessment test; clinical assessment; clinical effectiveness; controlled study; disease exacerbation; drug efficacy; drug safety; female; forced expiratory volume; forced vital capacity; human; incidence; major clinical study; male; outcome assessment; pneumonia; prospective study; randomized controlled trial; risk assessment; risk factor; scoring system; chemically induced; complication; dose response; inhalational drug administration; pneumonia; Pulmonary Disease, Chronic Obstructive; Administration, Inhalation; Adrenal Cortex Hormones; Aged; Dose-Response Relationship, Drug; Female; Humans; Male; Pneumonia; Prospective Studies; Pulmonary Disease, Chronic Obstructive; Risk Factors | - |
dc.title | Chronic obstructive pulmonary disease treated with inhaled medium- or high-dose corticosteroids: A prospective and randomized study focusing on clinical efficacy and the risk of Pneumonia | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.2147/DDDT.S63100 | - |
dc.identifier.pmid | 24920884 | - |
dc.identifier.scopus | 2-s2.0-84901663502 | - |
dc.relation.pages | 601-607 | - |
dc.relation.journalvolume | 8 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Oncology | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-7528-7494 | - |
crisitem.author.orcid | 0000-0001-6330-6048 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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