https://scholars.lib.ntu.edu.tw/handle/123456789/523663
標題: | ATM polymorphisms and risk of lung cancer among never smokers | 作者: | Lo Y.-L. Hsiao C.-F. Jou Y.-S. Chang G.-C. Tsai Y.-H. Su W.-C. Chen Y.-M. Huang M.-S. Chen H.-L. PAN-CHYR YANG Chen C.-J. Hsiung C.A. |
關鍵字: | ATM; Case-control study; DNA double-strand breaks; Environmental tobacco smoke; Gene-environment interaction; Haplotype; Low-level exposure; Lung cancer; Never smokers; Polymorphism | 公開日期: | 2010 | 卷: | 69 | 期: | 2 | 起(迄)頁: | 148-154 | 來源出版物: | Lung Cancer | 摘要: | The ataxia-telangiectasia mutated (ATM) gene, an important caretaker of overall genome stability, is thought to play a role in the development of human malignancy. Therefore, we hypothesized that sequence variants in ATM may influence the disposition to lung cancer. In this hospital-based matched case-control study, nine ATM single nucleotide polymorphisms (rs189037, rs228597, rs228592, rs664677, rs609261, rs599558, rs609429, rs227062, and rs664982) were genotyped in 730 lung cancer patients and 730 healthy controls. Pairwise linkage disequilibrium among nine polymorphisms in the ATM gene was very high. None of the main effects of any of the ATM polymorphisms were related to the risk of lung cancer. Interestingly, ATM polymorphisms were significantly associated with lung cancer among never smokers, and the association was modulated by low-level exposure to carcinogens such as environmental tobacco smoke. When the haplotypes of nine ATM polymorphism sites were studied, no overall association between ATM haplotypes and risk of lung cancer was found. However, the frequency distribution of haplotypes between lung cancer cases and controls was significant in the never smokers (P=0.009), demonstrating that haplotypes have a significant effect on the risk of lung cancer. In conclusion, we found that never smokers with sequence variants of the ATM gene may be at increased risk for lung cancer. Our data also suggest this association may be further modified by exposure to environmental tobacco smoke. This study suggests support to the literature that ATM polymorphisms and environmental tobacco smoke exposure have a role in lung carcinogenesis among never smokers. ? 2009 Elsevier Ireland Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77954143562&doi=10.1016%2fj.lungcan.2009.11.007&partnerID=40&md5=453d2996607f6407cd1ae69aa74cbe20 https://scholars.lib.ntu.edu.tw/handle/123456789/523663 |
ISSN: | 0169-5002 | DOI: | 10.1016/j.lungcan.2009.11.007 | SDG/關鍵字: | ATM protein; carcinogen; adult; article; cancer risk; carcinogenesis; controlled study; environmental exposure; female; gene frequency; gene linkage disequilibrium; gene sequence; genetic association; genetic risk; genetic variability; genotype; hospital based case control study; human; lung cancer; major clinical study; male; passive smoking; priority journal; risk assessment; single nucleotide polymorphism; Case-Control Studies; Cell Cycle Proteins; DNA Mutational Analysis; DNA-Binding Proteins; Environmental Exposure; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Linkage Disequilibrium; Lung Neoplasms; Polymorphism, Genetic; Protein-Serine-Threonine Kinases; Risk Factors; Smoking; Tumor Suppressor Proteins |
顯示於: | 醫學系 |
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