https://scholars.lib.ntu.edu.tw/handle/123456789/523762
標題: | Paradoxical response during anti-tuberculosis treatment in HIV-negative patients with pulmonary tuberculosis | 作者: | Cheng S.-L. HAO-CHIEN WANG PAN-CHYR YANG |
公開日期: | 2007 | 卷: | 11 | 期: | 12 | 起(迄)頁: | 1290-1295 | 來源出版物: | International Journal of Tuberculosis and Lung Disease | 摘要: | BACKGROUND: Transient worsening of tuberculosis (TB) symptoms and lesions following anti-tuberculosis treatment (paradoxical response [PR]), has been described in human immunodeficiency virus (HIV) infected patients who undergo anti-tuberculosis treatment. The frequency and clinical presentations for PR in HIV-negative patients with pulmonary TB are unknown. OBJECTIVE: To determine the incidence of PR and its associated manifestations in a retrospective study of HIV-negative patients with pulmonary TB. RESULTS: Of 659 TB patients, 16 developed PR, with an incidence of 2.4%. The medium onset time of PR was 26 days. Recurrent fever was the most common clinical manifestation. Compared with 643 patients without PR, patients developing PR had significantly decreased haemoglobin, albumin, body mass index and baseline lymphocyte counts. There was a noticeable increase in the lymphocyte count during paradoxical deterioration in PR subjects than in the control group. Independent factors for developing PR included anaemia, hypoalbuminaemia, lymphopaenia and lymphocyte count increase during PR development. CONCLUSIONS: The clinical manifestations of PR in patients with pulmonary TB were different from those in patients with extra-pulmonary TB. Baseline anaemia, hypoalbuminaemia, lymphopaenia and a greater change in lymphocyte count were independent risk factors for developing PR. ? 2007 The Union. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-37549054660&partnerID=40&md5=de6df10c0b682ab297e2fa597d3d7e78 https://scholars.lib.ntu.edu.tw/handle/123456789/523762 |
ISSN: | 1027-3719 | SDG/關鍵字: | albumin; corticosteroid; hemoglobin; adult; aged; anemia; article; body mass; central nervous system; confidence interval; controlled study; female; human; hypoalbuminemia; lung tuberculosis; lymphocyte count; lymphocytopenia; major clinical study; male; multivariate analysis; priority journal; recurrent fever; risk factor; Antitubercular Agents; Chi-Square Distribution; Female; HIV Seronegativity; Humans; Incidence; Logistic Models; Male; Middle Aged; Retrospective Studies; Risk Factors; Treatment Outcome; Tuberculosis, Pulmonary |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。