https://scholars.lib.ntu.edu.tw/handle/123456789/523788
標題: | Antibody responses to pneumococcal polysaccharide vaccine in Taiwanese patients with chronic obstructive pulmonary disease | 作者: | Lai C.-C. LI-NA LEE CHONG-JEN YU Hseuh P.-R. PAN-CHYR YANG Kuo S.-H. KWEN-TAY LUH |
公開日期: | 2007 | 出版社: | Scientific Communications International Ltd | 卷: | 106 | 期: | 3 | 起(迄)頁: | 196-203 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/Purpose: A study was undertaken to assess the antibody responses to a 23-valent pneumococcal polysaccharide vaccine and clinical outcome in Taiwanese patients with chronic obstructive pulmonary disease (COPD). Methods: From January to December 1999, 80 Taiwanese patients with COPD were enrolled. Each patient received a 23-valent pneumococcal polysaccharide vaccine (Pneumovax 23). Specific IgG antibodies to pneumococcal capsular antigens of serotypes 4, 6B, 7F, 9V, 14, 18C, 19F, and 23F were measured before vaccination, and 6 weeks and 52 weeks after vaccination. Results: Detectable prevaccination IgG antibody (> 1 μg/mL) was found in the range of 27.5% of patients for serotype 7F to 96.2% for serotype 14. Antibody concentrations in prevaccination sera were not different between middle-aged (< 65 years old) and elderly patients (? 65 years old). The percentage of elderly patients with postvaccination antibody concentration > 2-fold higher than that prior to vaccination ranged from 84% for serotype 18C to 90% for serotypes 7F, 9V, and 19F. The change in antibody level (fold and absolute increases) postvaccination was not significantly different among the different age groups. Conclusion: Taiwanese elderly adults with COPD, even in advanced age can mount a significant antibody response to pneumococcal polysaccharide vaccine. This study may support the existing recommendation that pneumococcal vaccine be offered to persons ? 65 years old with COPD. ? 2007 Elsevier & Formosan Medical Association. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-34247509403&doi=10.1016%2fS0929-6646%2809%2960240-0&partnerID=40&md5=4f4c6c4a0dea16b4bcc93327111f13c1 https://scholars.lib.ntu.edu.tw/handle/123456789/523788 |
ISSN: | 0929-6646 | DOI: | 10.1016/S0929-6646(09)60240-0 | SDG/關鍵字: | immunoglobulin G; Pneumococcus vaccine; polysaccharide vaccine; adult; age distribution; aged; antibody response; antibody specificity; article; chronic obstructive lung disease; controlled study; drug indication; female; human; immunoglobulin blood level; major clinical study; male; serotype; Taiwan; treatment outcome; vaccination |
顯示於: | 醫學系 |
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