https://scholars.lib.ntu.edu.tw/handle/123456789/523811
標題: | Multifunctional transcription factor YY1: A therapeutic target in human cancer? | 作者: | Wang C.-C. Chen J.J.W. PAN-CHYR YANG |
關鍵字: | Apoptosis; Cell invasion; Differentiation; HLJ1; Transcriptional regulation; YY1 | 公開日期: | 2006 | 卷: | 10 | 期: | 2 | 起(迄)頁: | 253-266 | 來源出版物: | Expert Opinion on Therapeutic Targets | 摘要: | The multifunctional transcription factor Yin Yang 1 (YY1) is a complex protein that has been shown to play pivotal roles in development, differentiation, cellular proliferation and apoptosis. It can act as a transcriptional repressor, an activator, or an initiator element binding protein that directs and initiates transcription of numerous cellular and viral genes. Because the expression and function of YY1 are known to be intimately associated with cell-cycle progression, the physiological significance of YY1 activity has recently been applied to models of cancer biology. Several lines of evidence imply that YY1 expression and/or activation is associated with tumourigenesis, in addition to its regulatory roles in normal biological processes. However, controversial results also raised and indicated that further studies are still needed to piece all of the seemingly contradictory data into a complete picture. On the basis of YY1 regulations and functions, novel drugs and specific treatment strategies may be developed with new therapeutic applications for tumour patients in the future. ? 2006 Ashley Publications. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33645768457&doi=10.1517%2f14728222.10.2.253&partnerID=40&md5=99f765fca423d34eb51a6446390b0796 https://scholars.lib.ntu.edu.tw/handle/123456789/523811 |
ISSN: | 1472-8222 | DOI: | 10.1517/14728222.10.2.253 | SDG/關鍵字: | CD31 antigen; cisplatin; cytotoxic agent; death receptor; epidermal growth factor receptor 2; Fas antigen; FAS ligand; galactosylceramidase; gamma interferon; gene product; histone deacetylase 1; histone deacetylase inhibitor; immunoglobulin enhancer binding protein; nitric oxide; protein p53; rituximab; transcription factor YY1; transforming growth factor beta; uvomorulin; virus DNA; amino acid sequence; antineoplastic activity; apoptosis; binding affinity; breast cancer; cancer cell; cancer immunotherapy; cancer inhibition; cancer resistance; carcinogenesis; cell cycle G0 phase; cell cycle G1 phase; cell cycle S phase; cell differentiation; cell invasion; cell migration; cell proliferation; DNA binding; drug mechanism; drug targeting; embryo development; embryo pattern formation; enzyme activity; Epstein Barr virus; gene activation; gene expression regulation; gene mutation; gene overexpression; gene targeting; gene translocation; genetic code; Hepatitis B virus; human; human development; Human immunodeficiency virus 1; Human papillomavirus type 16; Human papillomavirus type 18; immunohistochemistry; long terminal repeat; malignant neoplastic disease; metastasis potential; mutational analysis; myeloid leukemia; nonhuman; promoter region; prostate cancer; protein binding; protein determination; protein expression; protein function; protein localization; protein protein interaction; protein stability; protein targeting; protein transport; regulatory mechanism; review; transcription initiation; transcription regulation; virus gene; virus replication; virus strain; Animals; Antineoplastic Agents; Drug Delivery Systems; Humans; Neoplasms; YY1 Transcription Factor |
顯示於: | 醫學系 |
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