https://scholars.lib.ntu.edu.tw/handle/123456789/524257
標題: | Genetic variation-optimized treatment benefit of angiotensin-converting enzyme inhibitors in patients with stable coronary artery disease: A 12-year follow-up study | 作者: | JEN-KUANG LEE CHO-KAI WU CHIA-TI TSAI LIAN-YU LIN JOU-WEI LIN KUO-LIONG CHIEN HWANG, JUEY-JEN Lin C.-L. Tseng C.-D. FU-TIEN CHIANG |
公開日期: | 2013 | 出版社: | Lippincott Williams and Wilkins | 卷: | 23 | 期: | 4 | 起(迄)頁: | 181-189 | 來源出版物: | Pharmacogenetics and Genomics | 摘要: | OBJECTIVES: The objective of this study was to examine the relationship between renin-angiotensin system genotypes and the pharmacogenetics of angiotensin-converting enzyme (ACE) inhibitors in Chinese patients with coronary artery disease (CAD). METHODS: Patients with angiographic CAD were recruited from 1995 to 2003. The baseline characteristics and genetic polymorphisms [ACE gene insertion/deletion (I/D) polymorphisms, six polymorphisms of the angiotensinogen (AGT) gene, and A-1166C polymorphisms of the angiotensin-II type I receptor gene (AGT1R)] were established. Patients were divided into two groups (ACE inhibitor or no ACE inhibitor) and followed for up to 12 years. Kaplan-Meier curves and Cox regression models were used to determine the survival and major cardiovascular events (MACE) event-free survival trends. Pharmacogenetic effects were determined by several Cox regression models. RESULTS: Of the 784 patients, 432 were treated with ACE inhibitors and 352 were not. ACE inhibitors were associated with a lower MACE rate at 4000 days. In addition, the ACE I/D gene D and AGT1R gene C alleles were associated with a higher MACE rate on the basis of a multivariate regression analysis. This effect was attenuated by the pharmacogenetic interaction of ACE inhibitors and the ACE gene (ACE inhibitors* ACE gene, hazard ratio: 0.8, 95% confidence interval: 0.62-0.94, P=0.03). CONCLUSIONS: ACE inhibitors were associated with a significant decrease in MACE in Chinese patients diagnosed with CAD. Genetic variants were also associated with event-free survival, but their effects were modified by the use of ACE inhibitors. ? 2013 Wolters Kluwer Health | Lippincott Williams &Wilkins. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84874935630&doi=10.1097%2fFPC.0b013e32835a0ffa&partnerID=40&md5=f6056cd5ad8d554e4c3723c9d0a78ea0 https://scholars.lib.ntu.edu.tw/handle/123456789/524257 |
ISSN: | 1744-6872 | DOI: | 10.1097/FPC.0b013e32835a0ffa | SDG/關鍵字: | angiotensin 1 receptor; angiotensinogen; dipeptidyl carboxypeptidase; dipeptidyl carboxypeptidase inhibitor; adult; allele; angiocardiography; article; cardiovascular disease; Chinese; confidence interval; controlled study; coronary artery disease; drug effect; event free survival; female; follow up; gene deletion; gene insertion; gene interaction; genetic polymorphism; genetic variability; genotype; hazard ratio; human; human tissue; Kaplan Meier method; major clinical study; male; multivariate logistic regression analysis; outcome assessment; pharmacogenetics; priority journal; proportional hazards model; renin angiotensin aldosterone system; statistical significance; survival |
顯示於: | 醫學系 |
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