https://scholars.lib.ntu.edu.tw/handle/123456789/524274
標題: | Renal-related biomarkers and long-term mortality in the US subjects with different coronary risks | 作者: | CHO-KAI WU Chang M.-H. JOU-WEI LIN Caffrey J.L. Lin Y.-S. |
關鍵字: | Biological markers; Kidney function tests; Nutrition surveys; Risk assessment | 公開日期: | 2011 | 卷: | 216 | 期: | 1 | 起(迄)頁: | 226-236 | 來源出版物: | Atherosclerosis | 摘要: | Objective: The objective was to evaluate the association of a panel of renal biomarkers with long-term mortalities. Methods: Participants in the Third National Health and Nutrition Examination Survey (NHANES III) aged 35 years and above were included and Framingham risk scores were calculated. Renal-related biomarkers, including creatinine-based estimated glomerular filtration rate (eGFR), cystatin C, uric acid, C-reactive protein (CRP), fibrinogen, urinary cadmium, albuminuria, homocysteine, and vitamin D were tested by Cox-regression model for their association with all-cause, cardiovascular (CV), and non-CV mortality obtained from the 2006 NHANES III-linked follow-up data, stratified by sex and Framingham risk. Results: In the 4873 men and 5372 women, 36.3%, 28.1%, and 35.6% of men and 67.2%, 25.8%, and 7.0% of women were classified into low-, intermediate-, and high coronary risk groups. With an average follow-up of 13.2 years, a total of 3632 deaths and 1657 CV deaths were recorded. Albuminuria was associated with all-cause mortality in both sexes across coronary risk groups. Creatinine-based eGFR provided additional differential capacity only in the women with intermediate-to-high coronary risk. Cystatin C was associated with all-cause mortality in the men with intermediate-to-high coronary risk and with CV mortality in the women with low coronary risk. Urinary cadmium was positively related to non-CV mortality. High vitamin D was protective against cardiovascular mortality in a limited category of men and women. Conclusions: Albuminuria is associated with long-term all-cause mortalities independent of Framingham risks. Adding the panel of renal biomarkers provides limited advantages for predicting risk when compared to FRS alone. ? 2011 Elsevier Ireland Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79955532344&doi=10.1016%2fj.atherosclerosis.2011.01.046&partnerID=40&md5=2b37fe2cf38da71bc016ad1c80d0dee3 https://scholars.lib.ntu.edu.tw/handle/123456789/524274 |
ISSN: | 0021-9150 | DOI: | 10.1016/j.atherosclerosis.2011.01.046 | SDG/關鍵字: | biological marker; C reactive protein; cadmium; creatinine; cystatin C; fibrinogen; homocysteine; uric acid; vitamin D; adult; aged; albuminuria; article; coronary risk; female; follow up; glomerulus filtration rate; hazard ratio; health survey; human; male; mortality; priority journal; scoring system; United States; urine level; Adult; Aged; Albuminuria; Biological Markers; Chi-Square Distribution; Coronary Disease; Female; Glomerular Filtration Rate; Humans; Kidney; Kidney Diseases; Male; Middle Aged; Nutrition Surveys; Prognosis; Proportional Hazards Models; Risk Assessment; Risk Factors; Survival Analysis; Time Factors; United States |
顯示於: | 醫學系 |
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