https://scholars.lib.ntu.edu.tw/handle/123456789/524909
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Cheng C.-L. | en_US |
dc.contributor.author | Yang S.-C. | en_US |
dc.contributor.author | Lai C.-Y. | en_US |
dc.contributor.author | Wang C.-K. | en_US |
dc.contributor.author | Chang C.-F. | en_US |
dc.contributor.author | Lin C.-Y. | en_US |
dc.contributor.author | Chen W.-J. | en_US |
dc.contributor.author | Lin P.-Y. | en_US |
dc.contributor.author | Wu H.-C. | en_US |
dc.contributor.author | Ma N. | en_US |
dc.contributor.author | FRANK LEIGH LU | en_US |
dc.contributor.author | Lu J. | en_US |
dc.creator | Cheng C.-L.;Yang S.-C.;Lai C.-Y.;Wang C.-K.;Chang C.-F.;Lin C.-Y.;Chen W.-J.;Lin P.-Y.;Wu H.-C.;Ma N.;Frank Leigh Lu;Lu J. | - |
dc.date.accessioned | 2020-12-08T03:28:47Z | - |
dc.date.available | 2020-12-08T03:28:47Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85088675764&doi=10.3390%2fcells9071706&partnerID=40&md5=1be23755037453b8ba5808d800e02821 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/524909 | - |
dc.description.abstract | Human embryonic stem cells (hESCs) have important roles in regenerative medicine, but only a few studies have investigated the cytokines secreted by hESCs. We screened and identified chemokine (C-X-C motif) ligand 14 (CXCL14), which plays crucial roles in hESC renewal. CXCL14, a C-X-C motif chemokine, is also named as breast and kidney-expressed chemokine (BRAK), B cell and monocyte-activated chemokine (BMAC), and macrophage inflammatory protein-2γ (MIP-2γ). Knockdown of CXCL14 disrupted the hESC self-renewal, changed cell cycle distribution, and further increased the expression levels of mesoderm and endoderm differentiated markers. Interestingly, we demonstrated that CXCL14 is the ligand for the insulin-like growth factor 1 receptor (IGF-1R), and it can activate IGF-1R signal transduction to support hESC renewal. Currently published literature indicates that all receptors in the CXCL family are G protein-coupled receptors (GPCRs). This report is the first to demonstrate that a CXCL protein can bind to and activate a receptor tyrosine kinase (RTK), and also the first to show that IGF-1R has another ligand in addition to IGFs. These findings broaden our understanding of stem cell biology and signal transduction. | - |
dc.publisher | NLM (Medline) | - |
dc.relation.ispartof | Cells | - |
dc.subject | BMAC; BRAK; cell cycle; CXCL14; human embryonic stem cell; IGF-1R; Mip-2γ; self-renewal | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | alpha chemokine; CXCL14 protein, human; IGF1R protein, human; protein binding; small interfering RNA; somatomedin C receptor; biological model; cell cycle; cell differentiation; cell line; cell self-renewal; cytology; drug effect; gene knockdown; human; human embryonic stem cell; metabolism; signal transduction; Cell Cycle; Cell Differentiation; Cell Line; Cell Self Renewal; Chemokines, CXC; Gene Knockdown Techniques; Human Embryonic Stem Cells; Humans; Models, Biological; Protein Binding; Receptor, IGF Type 1; RNA, Small Interfering; Signal Transduction | - |
dc.title | CXCL14 Maintains hESC Self-Renewal through Binding to IGF-1R and Activation of the IGF-1R Pathway | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.3390/cells9071706 | - |
dc.identifier.pmid | 32708730 | - |
dc.identifier.scopus | 2-s2.0-85088675764 | - |
dc.relation.journalvolume | 9 | - |
dc.relation.journalissue | 7 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Child Protection Center | - |
crisitem.author.orcid | 0000-0002-5225-7751 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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