https://scholars.lib.ntu.edu.tw/handle/123456789/524937
標題: | Pulmonary responses to subacute ozone exposure in obese vs. lean mice | 作者: | Shore S.A. Lang J.E. Kasahara D.I. FRANK LEIGH LU Verbout N.G. Si H. Williams E.S. Terry R.D. Lee A. Johnston R.A. |
關鍵字: | Dynamic compliance; Macrophage; Neutrophil; Pulmonary resistance; sTNFR1 | 公開日期: | 2009 | 卷: | 107 | 期: | 5 | 起(迄)頁: | 1445-1452 | 來源出版物: | Journal of Applied Physiology | 摘要: | The purpose of this study was to determine whether obesity affects pulmonary responses following a 3-day ozone exposure. Obese db/db and lean wild-type mice were exposed to ozone (0.3 ppm) for 72 h. In wild-type mice, ozone exposure caused pulmonary injury and inflammation, and these events were associated with reduced pulmonary compliance. In db/db mice, ozone-induced neutrophil recruitment to the lung was reduced and no reduction in compliance was observed. Similar results were obtained in obese Cpefat mice, indicating that loss of leptin signaling in db/db mice does not account for these obesity-related changes. To examine the role of interleukin (IL)-6 in this obesity-related difference in ozone responsiveness, wild-type and IL-6-deficient mice were raised on 10% or 60% fat diets. Compared with 10% fat-fed mice, wild-type 60% fat-fed mice were obese and had reduced neutrophil recruitment following ozone. IL-6 deficiency reduced ozone-induced neutrophil recruitment in 10% fat-fed mice. In contrast, in obese mice, no effect of IL-6 deficiency on neutrophil recruitment was observed. Obesity-related differences in the effect of ozone on compliance were observed in both wild-type and IL-6-deficient mice. Obesity-related differences in serum IL-6 were observed and may account for obesityrelated differences in the effect of IL-6 deficiency on neutrophil recruitment. In summary, the neutrophilic inflammation induced by prolonged low level ozone exposure was attenuated in obese mice and appeared to result from an absence of IL-6-dependent neutrophil recruitment in the obese mice. Copyright ? 2009 the American Physiological Society. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-72749111392&doi=10.1152%2fjapplphysiol.00456.2009&partnerID=40&md5=67ae9976eecc90e06b7dba3b92a43444 https://scholars.lib.ntu.edu.tw/handle/123456789/524937 |
ISSN: | 8750-7587 | DOI: | 10.1152/japplphysiol.00456.2009 | SDG/關鍵字: | interleukin 6; leptin; ozone; animal experiment; animal model; article; controlled study; female; lung compliance; lung function; lung injury; male; mouse; nonhuman; obesity; pneumonia; priority journal; protein function; signal transduction; Animals; Environmental Exposure; Interleukin-6; Lung; Mice; Obesity; Ozone; Respiratory Mechanics; Thinness |
顯示於: | 醫學系 |
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