https://scholars.lib.ntu.edu.tw/handle/123456789/524975
標題: | Enterovirus D68 seroepidemiology in Taiwan, a cross sectional study from 2017 | 作者: | JIAN-TE LEE WEI-LIANG SHIH TING-YU YEN Cheng A.-L. CHUN-YI LU LUAN-YIN CHANG LI-MIN HUANG |
公開日期: | 2020 | 出版社: | Public Library of Science | 卷: | 15 | 期: | 3 | 起(迄)頁: | e0230180 | 來源出版物: | PLoS ONE | 摘要: | Background Enterovirus D68 (EV-D68) was discovered in 1962 and has unique characteristics compared to the characteristics of other enteroviruses. There were few documented cases before the epidemic in the United States in 2014. The Taiwan Centers for Diseases Control also confirmed that EV-D68 has been endemic, and some cases of acute flaccid myelitis were reported in Taiwan. To understand the current EV-D68 serostatus, we performed an EV-D68 seroepidemiology study in Taiwan in 2017. Methods After informed consent was obtained, we enrolled preschool children, 6- to 15-year-old students and 16- to 49-year-old people. The participants underwent a questionnaire investigation and blood sampling to measure the EV-D68 neutralization antibody. Results In total, 920 subjects were enrolled from the northern, central, southern and eastern parts of Taiwan with a male-to-female ratio of 1.03. The EV-D68 seropositive rate was 32% (26/82) in infants, 18% (27/153) in 1-year-old children, 43% (36/83) in 2-year-old children, 60% (94/ 156) in 3- to 5-year-old children, 89% (108/122) in 6- to 11-year-old primary school students, 98% (118/121) in 12- to 15-year-old high school students, 100% (122/122) in 16- to 49-year-old women and 100% (81/81) in 16- to 49-year-old males in 2017. Among preschool children, EV-D68 seropositivity was related to age (p for trend <0.0001), size of household ≧4 members (p = 0.037) and kindergarten attendance (p = 0.027). The seropositive rate varied among different geographic regions. Conclusion EV-D68 infection was prevalent, and its seropositive rates increased with age, larger household size and kindergarten attendance among preschool children. ? 2020 Lee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081212608&doi=10.1371%2fjournal.pone.0230180&partnerID=40&md5=d86f2f39c71d0966e275f89eabfcf8f5 https://scholars.lib.ntu.edu.tw/handle/123456789/524975 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0230180 | SDG/關鍵字: | neutralizing antibody; neutralizing antibody; adolescent; adult; antibody blood level; Article; blood sampling; child; cross-sectional study; Enterovirus D68; Enterovirus infection; female; geography; groups by age; high school student; household; human; major clinical study; male; preschool child; primary school; questionnaire; risk factor; seroepidemiology; Taiwan; blood; Enterovirus D; Enterovirus infection; epidemic; infant; middle aged; pathogenicity; seroepidemiology; Adolescent; Adult; Antibodies, Neutralizing; Child; Child, Preschool; Cross-Sectional Studies; Disease Outbreaks; Enterovirus D, Human; Enterovirus Infections; Female; Humans; Infant; Male; Middle Aged; Seroepidemiologic Studies; Taiwan |
顯示於: | 醫學系 |
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