https://scholars.lib.ntu.edu.tw/handle/123456789/525040
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | JYH-HONG LEE | en_US |
dc.contributor.author | YU-TSAN LIN | en_US |
dc.contributor.author | YAO-HSU YANG | en_US |
dc.contributor.author | LI-CHIEH WANG | en_US |
dc.contributor.author | BOR-LUEN CHIANG | en_US |
dc.creator | Jyh-Hong Lee;Lin Y.-T.;Yang Y.-H.;Wang L.-C.;Chiang B.-L. | - |
dc.date.accessioned | 2020-12-08T08:20:32Z | - |
dc.date.available | 2020-12-08T08:20:32Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1018-2438 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-27844487558&doi=10.1159%2f000088868&partnerID=40&md5=56b07dc0cfd5154e2ee16c52b0ea8cec | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/525040 | - |
dc.description.abstract | Background: The association between staphylococcal enterotoxins and atopic dermatitis (AD) is well characterized. We aim to evaluate the association between sensitization to staphylococcal enterotoxin A (SEA) and/or B (SEB) and the development of allergic airway disease. Methods: Two hundred and seventy-four patients were grouped into allergic rhinitis (AR) and/or bronchial asthma (BA) only, AD only and AR/BA+AD. The AR/BA only group was further divided into AR only, AR and airway hyperresponsiveness (AR+AHR) and BA. The allergen-specific and total immunoglobulin E (IgE) antibodies were determined by the CAP system. The associations of sensitization to SEA/SEB with allergic airway disease were analyzed by logistic regression analysis. Results: The overall rate of sensitization to SEA/SEB was 25.7%, whereas the rate of the AD only group (45.5%) was significantly higher than that of the AR/BA only group (24.5%, χ2 = 8.1). After sensitization to SEA/SEB, the geometric mean total IgE levels were significantly elevated in patients with AR+AHR and BA, but not in those with AR only. BA patients had higher geometric mean values of SEA- and SEB-specific IgE than AR only and AR+AHR patients. Logistic regression revealed that AR/BA only was more associated with sensitization to SEA/SEB (odds ratio 6.57) than AD only and AR/BA+AD (odds ratio 2.44 and 1.72). Conclusions: Atopic status after sensitization to SEA/SEB was more closely associated with BA than with other airway allergy, implying that SEA/SEB may play a role in exacerbating airway allergy and increasing the risk of allergic airway disease. Our study suggests that staphylococcal enterotoxins play a prominent role in the pathogenesis of allergic airway disease as well as AD. Copyright ? 2005 S. Karger AG. | - |
dc.relation.ispartof | International Archives of Allergy and Immunology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | allergen; immunoglobulin E; Staphylococcus enterotoxin A; Staphylococcus enterotoxin B; adolescent; adult; allergic asthma; allergic rhinitis; antibody detection; antigen specificity; article; asthma; atopic dermatitis; child; controlled study; disease association; disease exacerbation; female; geometry; human; immunoglobulin blood level; infant; logistic regression analysis; major clinical study; male; newborn; pathogenesis; priority journal; quantitative analysis; respiratory tract allergy; risk factor; sensitization; Adolescent; Adult; Age Factors; Antigens, Dermatophagoides; Asthma; Child; Child, Preschool; Dermatitis, Atopic; Enterotoxins; Female; Humans; Immunization; Immunoglobulin E; Male; Rhinitis, Allergic, Perennial; Sex Factors; Statistics, Nonparametric | - |
dc.title | Increased levels of serum-specific immunoglobulin E to staphylococcal enterotoxin A and B in patients with allergic rhinitis and bronchial asthma | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1159/000088868 | - |
dc.identifier.pmid | 16224190 | - |
dc.identifier.scopus | 2-s2.0-27844487558 | - |
dc.relation.pages | 305-311 | - |
dc.relation.journalvolume | 138 | - |
dc.relation.journalissue | 4 | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Oral Biology | - |
crisitem.author.dept | College of Life Science | - |
crisitem.author.dept | Immunology | - |
crisitem.author.orcid | 0000-0003-4285-4912 | - |
crisitem.author.orcid | 0000-0002-4192-3165 | - |
crisitem.author.orcid | 0000-0002-6266-9864 | - |
crisitem.author.orcid | 0000-0002-5773-1627 | - |
crisitem.author.orcid | 0000-0002-6705-0286 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University | - |
crisitem.author.parentorg | College of Medicine | - |
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