https://scholars.lib.ntu.edu.tw/handle/123456789/525217
標題: | High-resolution melting analyses for genetic variants in ARID5B and IKZF1 with childhood acute lymphoblastic leukemia susceptibility loci in Taiwan | 作者: | Lin C.-Y. MENG-JU LI Chang J.-G. Liu S.-C. Weng T. Wu K.-H. Yang S.-F. Huang F.-K. Lo W.-Y. Peng C.-T. |
關鍵字: | ARID5B; Childhood acute lymphoblastic leukemia; High-resolution melting analyses; IKZF1; Single nucleotide polymorphisms | 公開日期: | 2014 | 卷: | 52 | 期: | 2ค๋3ค้ | 起(迄)頁: | 140-145 | 來源出版物: | Blood Cells, Molecules, and Diseases | 摘要: | Background: Childhood acute lymphoblastic leukemia (ALL), a heterogeneous disease that includes multiple subtypes is defined by cell lineage and chromosome anomalies. Previous genome-wide association studies have reported several ARID5B and IKZF1 single nucleotide polymorphisms (SNPs) associated with the incidence of ALL. High-resolution melting (HRM) analysis is a rapid and convenient technique to detect SNPs; we thereby detected SNPs in ARID5B and IKZF1 genes. Methods: We enrolled 79 pediatric ALL patients and 80 healthy controls. Polymorphic variants of IKZF1 (rs6964823, rs4132601, and rs6944602) and ARID5B (rs7073837, rs10740055, and rs7089424) were detected by HRM, and SNPs were analyzed for association with childhood ALL. Results: The distribution of genotype rs7073837 in ARID5B significantly differed between ALL and controls (P= 0.046), while those of IKZF1 (rs6964823, rs4132601, and rs6944602) and ARID5B (rs10740055 and rs7089424) did not. We analyzed the association for SNPs with B lineage ALL to find rs7073837 in ARID5B, conferring a higher risk for B lineage ALL (odds ratio, OR = 1.70, 95% confidence interval, CI = 1.01-2.87, P= 0.049). Conclusion: HRM is a practical method to detect SNPs in ARID5B and IKZF1 genes. We found that rs7073837 in ARID5B correlated with a risk for childhood B lineage ALL. ? 2013 Elsevier Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84891902087&doi=10.1016%2fj.bcmd.2013.10.003&partnerID=40&md5=bd1e249cd3d6dde1677fc65f937d5dec https://scholars.lib.ntu.edu.tw/handle/123456789/525217 |
ISSN: | 1079-9796 | DOI: | 10.1016/j.bcmd.2013.10.003 | SDG/關鍵字: | acute lymphoblastic leukemia; adolescent; ARID5B gene; article; childhood leukemia; chromosome aberration; controlled study; gene; gene locus; genetic association; genetic identification; genetic susceptibility; genetic variability; genotype; high resolution melting analysis; human; IKZF1 gene; incidence; major clinical study; point mutation; priority journal; single nucleotide polymorphism; Taiwan; ARID5B; Childhood acute lymphoblastic leukemia; High-resolution melting analyses; IKZF1; Single nucleotide polymorphisms; Adolescent; Alleles; Case-Control Studies; Child; Child, Preschool; DNA-Binding Proteins; Gene Frequency; Genetic Predisposition to Disease; Genetic Variation; Genotype; Humans; Ikaros Transcription Factor; Infant; Infant, Newborn; Nucleic Acid Amplification Techniques; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quantitative Trait Loci; Taiwan; Transcription Factors |
顯示於: | 醫學系 |
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