https://scholars.lib.ntu.edu.tw/handle/123456789/525471
標題: | Clinical features and risk factors associated with bacteremia of nontyphoidal salmonellosis in pediatric patients, 2010-2018 | 作者: | Lee, C.-M. Lee, M.-S. Yang, T.-L. Lee, K.-L. TING-YU YEN CHUN-YI LU PO-REN HSUEH PING-ING LEE JONG-MIN CHEN LI-MIN HUANG LUAN-YIN CHANG |
公開日期: | 2021 | 出版社: | NLM (Medline) | 卷: | 120 | 期: | 1 | 起(迄)頁: | 196-203 | 來源出版物: | Journal of the Formosan Medical Association = Taiwan yi zhi | 摘要: | Background/purpose(s): This study aimed to investigate clinical features and antimicrobial susceptibility of inpatient children with nontyphoidal salmonellosis from 2010 to 2018. Methods: We retrospectively collected pediatric patients with nontyphoidal Salmonella infection confirmed by positive cultures in a tertiary medical center in Taiwan from 2010 to 2018. Patients' characteristics, clinical manifestations, and laboratory data were collected. Serogroup category and antimicrobial susceptibility were also analyzed. Results: Of total 569 isolates, ampicillin resistant rate was 53% in average, third-generation cephalosporin resistant rate was 6.7%, ciprofloxacin resistant rate was 9% and trimethoprim–sulfamethoxazole resistant rate was 30%. Compared to the resistant rates in 2010, the resistance rate of third generation cephalosporin was significantly higher (3.4% vs. 11%, p = 0.003) but that of ciprofloxacin was significantly lower (20% vs. 11%, p < 0.001) in 2018. Among 297 inpatients with nontyphoidal salmonellosis, Group D (38%) was the most common in the bacteremia patients whereas Group B (48%) was the most common in the non-bacteremia patients. Among 244 immunocompetent inpatients with community-acquired salmonellosis, the bacteremia patients had significantly longer fever duration and diarrhea duration before hospitalization (p < 0.001), and significant higher rate of anemia (p = 0.028) due to either thalassemia trait or prolonged disease course than the non-bacteremia patients. Conclusion: Third-generation cephalosporin was still the drug of choice for nontyphoidal Salmonella infection in children though the resistant rate increased progressively. Significant risk factors associated with bacteremia were longer fever and diarrhea duration and anemia due to either thalassemia trait or prolonged disease course in immunocompetent children. ? 2020 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097003623&doi=10.1016%2fj.jfma.2020.04.022&partnerID=40&md5=7b9d80204f631cba13791f72bb50e2a5 https://scholars.lib.ntu.edu.tw/handle/123456789/525471 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2020.04.022 | SDG/關鍵字: | ampicillin; C reactive protein; ceftazidime; ceftriaxone; cephalosporin; ciprofloxacin; cotrimoxazole; hemoglobin; immunosuppressive agent; steroid; antiinfective agent; ampicillin resistance; anemia; antibiotic sensitivity; Article; autoimmune disease; bacteremia; cephalosporin resistance; child; ciprofloxacin resistance; clinical feature; cohort analysis; diarrhea; disease course; disease duration; female; fever; hemoglobin blood level; human; immunocompromised patient; immunosuppressive treatment; major clinical study; male; microcytic anemia; nontyphoidal salmonellosis; organ transplantation; protein blood level; retrospective study; risk factor; salmonellosis; steroid therapy; thalassemia; bacteremia; risk factor; salmonellosis; Taiwan; Anti-Bacterial Agents; Bacteremia; Child; Humans; Retrospective Studies; Risk Factors; Salmonella Infections; Taiwan |
顯示於: | 醫學系 |
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