https://scholars.lib.ntu.edu.tw/handle/123456789/525501
標題: | Molecular epidemiology and clinical features of adenovirus infection in Taiwanese children, 2014 | 作者: | Lin G.-L. CHUN-YI LU JONG-MIN CHEN PING-ING LEE Ho S.-Y. Weng K.-C. LI-MIN HUANG LUAN-YIN CHANG |
公開日期: | 2019 | 出版社: | Elsevier Ltd | 卷: | 52 | 期: | 2 | 起(迄)頁: | 215-224 | 來源出版物: | Journal of Microbiology, Immunology and Infection | 摘要: | Background/purposes: Human adenovirus (HAdV) infection is prevalent and has an important clinical impact on children. We aim to investigate the molecular epidemiology of HAdV infection and discover the correlations between clinical features and HAdV species in an HAdV outbreak of 2014. Methods: This is a retrospective study, enrolling patients under 19 years of age with HAdV infection at the National Taiwan University Hospital in 2014. We gathered the demographic and clinical data, carried out molecular typing and constructed a phylogenetic tree. Statistical analyses were performed in terms of HAdV species and hospitalization. Results: A total of 531 patients with HAdV infection were identified. HAdV-B accounted for the largest proportion (n = 387, 73%). On average, patients infected with HAdV-E were oldest, whereas those with HAdV-C infection were youngest (p < 0.001). Patients with HAdV-B (HAdV-3) infection were associated with a lower incidence of co-infection with other viruses (p < 0.001). Complications occurred in 203 (38%) patients. There were 149 (28%) patients requiring hospitalization. The risk factors for hospitalization included underlying neurological abnormalities, prematurity and the diagnosis of pneumonia. Five patients (1%) had severe HAdV infection requiring intensive care; all of them fully recovered. The phylogenetic study showed that the partial hexon genes of HAdV-1, HAdV-3, HAdV-4 and HAdV-5 remain stable over time. Conclusion: We established the molecular epidemiology of HAdV infection and demonstrated the relationship between clinical features and HAdV species. ? 2018 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85054165015&doi=10.1016%2fj.jmii.2018.07.005&partnerID=40&md5=d595e787c5236c533aa875c76f23724f https://scholars.lib.ntu.edu.tw/handle/123456789/525501 |
ISSN: | 1684-1182 | DOI: | 10.1016/j.jmii.2018.07.005 | SDG/關鍵字: | adenovirus infection; adolescent; Article; child; clinical feature; epidemic; female; hospital patient; hospitalization; human; Human adenovirus B; Human adenovirus C; Human adenovirus E; infant; intensive care; major clinical study; male; mixed infection; molecular diagnosis; molecular epidemiology; molecular typing; neurologic disease; newborn; outpatient; pediatric patient; phylogenetic tree; pneumonia; prematurity; retrospective study; risk factor; Taiwanese; virus isolation; classification; DNA sequence; genetics; human adenovirus infection; incidence; molecular typing; pathogenicity; phylogeny; preschool child; prevalence; Taiwan; virology; virus gene; capsid protein; hexon capsid protein, Adenovirus; virus DNA; Adenovirus Infections, Human; Adenoviruses, Human; Adolescent; Capsid Proteins; Child; Child, Preschool; Coinfection; Disease Outbreaks; DNA, Viral; Female; Genes, Viral; Hospitalization; Humans; Incidence; Infant; Male; Molecular Epidemiology; Molecular Typing; Phylogeny; Prevalence; Retrospective Studies; Risk Factors; Sequence Analysis, DNA; Taiwan |
顯示於: | 醫學系 |
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