https://scholars.lib.ntu.edu.tw/handle/123456789/525527
標題: | Increased frequency of peripheral venipunctures raises the risk of central-line associated bloodstream infection in neonates with peripherally inserted central venous catheters | 作者: | Cheng H.-Y. CHUN-YI LU LI-MIN HUANG PING-ING LEE JONG-MIN CHEN LUAN-YIN CHANG |
公開日期: | 2016 | 出版社: | Elsevier Ltd | 卷: | 49 | 期: | 2 | 起(迄)頁: | 230-236 | 來源出版物: | Journal of Microbiology, Immunology and Infection | 摘要: | Background/Purpose: Central-line associated bloodstream infection (CLA-BSI), which is mostly caused by coagulase-negative staphylococcus, is an important morbidity in neonatal intensive care units. Our study is aimed to identify the risk factors of CLA-BSI in neonates with peripherally inserted central venous catheters (PICCs). Methods: A retrospective cohort study of neonatal intensive care unit patients with a PICC insertion between January 1, 2011 and December 31, 2012 was conducted. We performed univariate and multivariate analyses with a logistic regression model to investigate the risk factors and the association between increased frequency of peripheral venipunctures during PICC use and the risk of CLA-BSI while adjusting for other variables. Results: There were 123 neonates included in our study. Thirteen CLA-BSIs were recorded within the follow-up period. The incidence of PICC-associated CLA-BSI was 4.99 per 1000 catheter-days. There was no statistically significant association between the risk of CLA-BSI and gestational age, birth weight, chronological age, or other comorbidities. However, the odds of CLS-BSI increased to 12 times if the patient received six or more venipunctures within the period without concurrent antibiotic use [odds ratio (OR), 11.94; p < 0.001]. The OR of CLA-BSIs increased by 16% per venipuncture during PICC use (OR, 1.14; p = 0.003). Conclusion: During PICC use, increased frequency of venipunctures, especially when there was no concurrent antibiotic use, substantially raises the risk of CLA-BSI. By decreasing unnecessary venipunctures during PICC use, PICC-associated CLA-BSI and further morbidities and mortalities can be prevented. ? 2014. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84904525148&doi=10.1016%2fj.jmii.2014.06.001&partnerID=40&md5=1a3a89ef802fc5cefe1ac0d399571961 https://scholars.lib.ntu.edu.tw/handle/123456789/525527 |
ISSN: | 1684-1182 | DOI: | 10.1016/j.jmii.2014.06.001 | SDG/關鍵字: | adverse effects; Catheter-Related Infections; central venous catheter; human; incidence; newborn; phlebotomy; retrospective study; risk factor; sepsis; Catheter-Related Infections; Central Venous Catheters; Humans; Incidence; Infant, Newborn; Phlebotomy; Retrospective Studies; Risk Factors; Sepsis |
顯示於: | 醫學系 |
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