https://scholars.lib.ntu.edu.tw/handle/123456789/525536
Title: | Transmission of acute infectious illness among cases of Kawasaki disease and their household members | Authors: | HSING-CHEN TSAI LUAN-YIN CHANG CHUN-YI LU PEI-LAN SHAO Fan T.-Y. Cheng A.-L. Hu J.-J. Yeh S.-J. Chang C.-C. LI-MIN HUANG |
Issue Date: | 2015 | Publisher: | Elsevier B.V. | Journal Volume: | 114 | Journal Issue: | 1 | Start page/Pages: | 72-76 | Source: | Journal of the Formosan Medical Association | Abstract: | Background/purpose: Kawasaki disease (KD) is a disease of unknown cause and the causative agent is most likely to be infectious in nature. To investigate the household transmission pattern of infectious illness and etiology, we thus initiated a prospective case and household study. Methods: We enrolled KD cases and their household members from February 2004 to September 2008. The KD cases and their household members accepted questionnaire-based interviews of the contact history, signs of infection, and symptoms to check whether clusters of infectious illness occurred. Results: A total of 142KD cases and 561 household members were enrolled. Among the 142KD cases, 136 cases (96%) were typical KD, and six (4%) were atypical KD. Of the 561 household members, 17% were siblings, 46% were parents, 18% were grandparents, and the others were cousins or babysitters. Prior to the onset of their KD illness, 66% (94/142) KD cases had contact with ill household members. On the same day of the onset of KD cases' illness, 4% (6/142) KD cases had household members with illness. After KD cases' disease onset, 70% (100/142) KD cases had at least one other family member with illness. Overall, 61% (343/561) of all the household members had acute infectious illness during KD cases' acute stage, and 92% (130/142) of the families had clusters of infectious illness. Conclusion: A total of 66% KD cases had positive contact with ill household members prior to their disease onset and 92% of families had clusters of infectious illness, so KD is strongly associated with infections. ? 2014. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84921325324&doi=10.1016%2fj.jfma.2014.07.005&partnerID=40&md5=409aab09332e33896540834980080079 https://scholars.lib.ntu.edu.tw/handle/123456789/525536 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2014.07.005 | SDG/Keyword: | acute disease; adult; Article; child; clinical feature; common cold; conjunctivitis; contact examination; coughing; desquamation; diarrhea; disease association; disease transmission; Enterovirus; family study; father; female; fever; grandparent; hand foot and mouth disease; household; human; Human adenovirus 2; Human respiratory syncytial virus; infection; Influenza virus; interview; lip; lower respiratory tract infection; lymphadenopathy; major clinical study; male; mother; mucocutaneous lymph node syndrome; pharyngitis; questionnaire; rash; rhinorrhea; sibling; syndrome; Taiwan; tongue; tonsillitis; upper respiratory tract infection; virus culture; clinical trial; communicable disease; complication; family; infant; mucocutaneous lymph node syndrome; multicenter study; preschool child; prospective study; transmission; Acute Disease; Child; Child, Preschool; Communicable Diseases; Family; Female; Humans; Infant; Male; Mucocutaneous Lymph Node Syndrome; Prospective Studies; Taiwan [SDGs]SDG3 |
Appears in Collections: | 醫學系 |
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