https://scholars.lib.ntu.edu.tw/handle/123456789/525549
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chiang Y.-P. | en_US |
dc.contributor.author | WANG-HUEI SHENG | en_US |
dc.contributor.author | PEI-LAN SHAO | en_US |
dc.contributor.author | Chi Y.-H. | en_US |
dc.contributor.author | Arthur Chen Y.-M. | en_US |
dc.contributor.author | Huang S.-W. | en_US |
dc.contributor.author | Shih H.-M. | en_US |
dc.contributor.author | LUAN-YIN CHANG | en_US |
dc.contributor.author | CHUN-YI LU | en_US |
dc.contributor.author | SHAN-CHWEN CHANG | en_US |
dc.contributor.author | CHIEN-CHING HUNG | en_US |
dc.contributor.author | LI-MIN HUANG | en_US |
dc.creator | Chiang Y.-P.;Sheng W.-H.;Shao P.-L.;Chi Y.-H.;Arthur Chen Y.-M.;Huang S.-W.;Shih H.-M.;Luan-Yin Chang;Lu C.-Y.;Chang S.-C.;Hung C.-C.;Huang L.-M. | - |
dc.date.accessioned | 2020-12-15T07:42:03Z | - |
dc.date.available | 2020-12-15T07:42:03Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 2352-3964 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84922059521&doi=10.1016%2fj.ebiom.2014.10.002&partnerID=40&md5=46953609f7a781ab7c4c6dcc60dba9f2 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/525549 | - |
dc.description.abstract | Individual differences in susceptibility to human immunodeficiency virus type 1 (HIV-1) infection have been of interest for decades. We aimed to determine the contribution of large isoform of Mammalian DnaJ (MRJ-L), a HIV-1 Vpr-interacting cellular protein, to this natural variation. Expression ofMRJ-L in monocyte-derived macrophages was significantly higher in HIV-infected individuals (n=31) than their uninfected counterparts (n=27) (p= 0.009). Fifty male homosexual subjects (20 of them are HIV-1 positive) were further recruited to examine the association between MRJ-L levels and occurrence of HIV infection. Bayesian multiple logistic regression revealed that playing a receptive role and increased levels of MRJ-L in macrophages were two risk factors for HIV-1 infection. A 1% rise in MRJ-L expression was associated with a 1.13 fold (95% CrI 1.06-1.29) increase in odds of contracting HIV-1 infection. Ex vivo experiments revealed that MRJ-L facilitated Vpr-dependent nuclear localization of virus. Infection ofmacrophage-tropic strain is a critical step in HIV-1 transmission.MRJ-L is a critical factor in this process; hence, subjects with higher macrophage MRJ-L levels are more vulnerable to HIV-1 infection. ? 2014 The Authors. | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.ispartof | EBioMedicine | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | lentivirus vector; phorbol 13 acetate 12 myristate; phytohemagglutinin; protein DnaJ; Vpr protein; adult; Article; CD4+ T lymphocyte; controlled study; disease association; disease predisposition; enzyme immunoassay; enzyme linked immunosorbent assay; genetic susceptibility; genetic transfection; homosexual male; human; Human immunodeficiency virus 1 infection; infection sensitivity; macrophage; major clinical study; male; men who have sex with men; priority journal; protein expression; questionnaire; risk factor; sequence analysis; serology; unsafe sex; Western blotting | - |
dc.title | Large isoform of mammalian relative of dnaJ is a major determinant of human susceptibility to HIV-1 infection | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.ebiom.2014.10.002 | - |
dc.identifier.scopus | 2-s2.0-84922059521 | - |
dc.relation.pages | 126-132 | - |
dc.relation.journalvolume | 1 | - |
dc.relation.journalissue | 2月3日 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Medical Education-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Pediatrics-NTUHHC | - |
crisitem.author.dept | Laboratory Medicine-NTUHHC | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Office of the Vice President | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Tropical Medicine and Parasitology | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | National Taiwan University Children's Hospital | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.orcid | 0000-0002-5605-7853 | - |
crisitem.author.orcid | 0000-0003-3334-1330 | - |
crisitem.author.orcid | 0000-0003-2632-1956 | - |
crisitem.author.orcid | 0000-0002-5240-2808 | - |
crisitem.author.orcid | 0000-0001-6505-4139 | - |
crisitem.author.orcid | 0000-0001-7345-0836 | - |
crisitem.author.orcid | 0000-0002-9291-260X | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | Administrative Unit | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
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