https://scholars.lib.ntu.edu.tw/handle/123456789/525567
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Tai C.-F. | en_US |
dc.contributor.author | Tsou T.-P. | en_US |
dc.contributor.author | Hsieh W.-S. | en_US |
dc.contributor.author | CHIEN-YI CHEN | en_US |
dc.contributor.author | HUNG-CHIEH CHOU | en_US |
dc.contributor.author | PO-NIEN TSAO | en_US |
dc.contributor.author | Hsu C.-H. | en_US |
dc.contributor.author | Liau Y.-J. | en_US |
dc.contributor.author | CHUN-YI LU | en_US |
dc.contributor.author | PEI-LAN SHAO | en_US |
dc.contributor.author | LUAN-YIN CHANG | en_US |
dc.contributor.author | LI-MIN HUANG | en_US |
dc.creator | Tai C.-F.;Tsou T.-P.;Hsieh W.-S.;Chen C.-Y.;Chou H.-C.;Tsao P.-N.;Hsu C.-H.;Liau Y.-J.;Lu C.-Y.;Shao P.-L.;Luan-Yin Chang;Huang L.-M. | - |
dc.date.accessioned | 2020-12-15T07:42:08Z | - |
dc.date.available | 2020-12-15T07:42:08Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1684-1182 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84861230432&doi=10.1016%2fj.jmii.2011.11.004&partnerID=40&md5=a72d354bcaef242ea9d0cbe23a628813 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/525567 | - |
dc.description.abstract | Background/Purpose: Human papillomavirus (HPV) infection can cause laryngeal papillomas in children. Vertical transmission has been confirmed. This study aimed to establish a sensitive molecular diagnostic method and understand the incidence of the HPV-6 and HPV-11 in neonates with intubation. Methods: We enrolled 108 newborns between October 2007 and January 2010. All neonates were intubated due to underlying disease. The specimens were collected via endotracheal aspiration. DNA of HPV types 6 and 11 was detected by real-time PCR and nested PCR. Results: HPV-DNA was detected in eight of the 108 newborns studied. Seven respiratory specimens tested positive for HPV-11 and one was positive for HPV-6. The HPV 6/11 detection rate in neonates was 7.4% (8/108). Conclusion: A rapid, sensitive, specific, and reproducible RT-PCR method and nest PCR were developed for the detection and differentiation of HPV-6 and HPV-11 genomic variants in a single PCR reaction. The assays are of great value for clinical and epidemiologic studies of HPV-6 and HPV-11 infections. Neonatal HPV colonization may be related to juvenile-onset recurrent respiratory papillomatosis. The transmission route may be from mother to child. The clinical significance of neonatal carriage of HPV-6 or HPV-11 warrants further study. ? 2012 . | - |
dc.relation.ispartof | Journal of Microbiology, Immunology and Infection | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | virus DNA; article; genetic variability; human; Human papillomavirus type 11; Human papillomavirus type 6; incidence; intubation; major clinical study; molecular diagnosis; newborn; pilot study; real time polymerase chain reaction; reproducibility; respiratory system; sensitivity and specificity; tracheal aspiration procedure; virus transmission; Academic Medical Centers; Base Sequence; Cohort Studies; DNA, Viral; Human papillomavirus 11; Human papillomavirus 6; Humans; Incidence; Infant, Newborn; Intubation, Intratracheal; Molecular Diagnostic Techniques; Molecular Sequence Data; Papillomavirus Infections; Pilot Projects; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity; Sequence Alignment | - |
dc.title | Molecular detection and incidence of human papillomavirus in neonates: Methodology and a pilot study in a medical center | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.jmii.2011.11.004 | - |
dc.identifier.pmid | 22571996 | - |
dc.identifier.scopus | 2-s2.0-84861230432 | - |
dc.relation.pages | 185-192 | - |
dc.relation.journalvolume | 45 | - |
dc.relation.journalissue | 3 | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Pediatrics-NTUHHC | - |
crisitem.author.dept | Laboratory Medicine-NTUHHC | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | National Taiwan University Children's Hospital | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.orcid | 0000-0002-6030-2655 | - |
crisitem.author.orcid | 0000-0002-8932-9472 | - |
crisitem.author.orcid | 0000-0002-6114-1769 | - |
crisitem.author.orcid | 0000-0002-5240-2808 | - |
crisitem.author.orcid | 0000-0003-3334-1330 | - |
crisitem.author.orcid | 0000-0003-2632-1956 | - |
crisitem.author.orcid | 0000-0002-9291-260X | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
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