https://scholars.lib.ntu.edu.tw/handle/123456789/525598| Title: | Immunogenicity and safety of a monovalent vaccine for the 2009 pandemic influenza virus A (H1N1) in children and adolescents | Authors: | CHUN-YI LU PEI-LAN SHAO LUAN-YIN CHANG Huang Y.-C. Chiu C.-H. Hsieh Y.-C. Lin T.-Y. LI-MIN HUANG |
Issue Date: | 2010 | Journal Volume: | 28 | Journal Issue: | 36 | Start page/Pages: | 5864-5870 | Source: | Vaccine | Abstract: | The 2009 pandemic influenza A (H1N1) has caused significant morbidity and mortality around the world. Safety and immunogenicity studies of 2009 pandemic influenza A (H1N1) virus in children and adolescents are limited. In this prospective, open-label study, 2 doses of a monovalent, unadjuvanted, inactivated, split-virus 2009 pandemic influenza virus A (H1N1) vaccine (AdimFlu-S) were administered to 183 healthy children and adolescents aged 1-17 years. Adverse reactions were assessed, and hemagglutination inhibition antibody titers were determined. Three weeks after the first dose, 36.2% of children aged 1-2 years, 52.5% of children aged 3-5 years, 56.7% of children aged 6-9 years, and 90.3% of adolescents aged 10-17 years generated protective antibodies. A second vaccination given 3 weeks later induced protective antibodies in 89.4% of all age groups. No severe adverse effects were found 6 weeks after vaccination. ? 2010 Elsevier Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77955551077&doi=10.1016%2fj.vaccine.2010.06.059&partnerID=40&md5=97c4510fe2f0c495543fc1a9f8791f1b https://scholars.lib.ntu.edu.tw/handle/123456789/525598 |
ISSN: | 0264-410X | DOI: | 10.1016/j.vaccine.2010.06.059 | SDG/Keyword: | adimflu s; hemagglutination inhibiting antibody; influenza vaccine; unclassified drug; adolescent; antibody response; antibody titer; arm movement; article; child; child care; clinical trial; coughing; drug fever; drug safety; ecchymosis; female; headache; human; immunogenicity; infant; influenza A (H1N1); injection site pain; injection site rash; injection site reaction; injection site redness; injection site swelling; major clinical study; malaise; male; myalgia; nausea; nose congestion; pandemic influenza; preschool child; priority journal; rhinopharyngitis; school child; side effect; sore throat; treatment response; upper respiratory tract infection; vaccination; vomiting; Adolescent; Antibodies, Viral; Child; Child, Preschool; Female; Hemagglutination Inhibition Tests; Humans; Immunization Schedule; Infant; Influenza A Virus, H1N1 Subtype; Influenza Vaccines; Influenza, Human; Male; Prospective Studies; Vaccines, Inactivated [SDGs]SDG3 |
| Appears in Collections: | 醫學系 |
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