https://scholars.lib.ntu.edu.tw/handle/123456789/525667
標題: | Predictors of unfavorable outcomes in enterovirus 71-related cardiopulmonary failure in children | 作者: | Hsia S.-H. Wu C.-T. Chang J.-J. Lin T.-Y. Chung H.-T. Lin K.-L. Hwang M.-S. Chou M.-L. LUAN-YIN CHANG |
關鍵字: | Cardiopulmonary failure; Enterovirus 71; Fatality; Predictor; Sequelae; Troponin I | 公開日期: | 2005 | 卷: | 24 | 期: | 4 | 起(迄)頁: | 331-334 | 來源出版物: | Pediatric Infectious Disease Journal | 摘要: | Background: Enterovirus 71 (EV71) can sometimes cause fatal or disabling diseases in children; therefore EV71-infected children with cardiopulmonary failure were investigated at Chang Gung Children's Hospital to discover the prognostic predictors. Methods: We investigated 27 EV71-infected children with cardiopulmonary failure from May 2000 to September 2001 and analyzed their clinical data to find predictors associated with unfavorable outcomes of deaths or ventilator dependence. Results: Of the 27 patients, 8 (30%) died and 10 (37%) were ventilator-dependent. Troponin I levels correlated most strongly with fatality, with 5 of the 6 children with troponin I levels >40 ng/ml dying (P = 0.001). Other factors correlated with fatality were cerebrospinal fluid white blood cell count ?100/μL (P = 0.002) and initial systolic pressure ?100 mm Hg (P = 0.05). Of the 19 survivors, 10 (53%) were left with central hypoventilation, dysphagia and/or limb weakness plus atrophy. The factors associated with ventilator dependence included higher inotrope equivalent (P < 0.001), duration of hypotension ?40 hours, initial blood systolic pressure ?100 mm Hg, positive EV71 isolation and age ?12 months. Conclusions: Poor prognostic factors were related to cardiovascular and neurologic damage; therefore physicians may consider advanced cardiovascular support for EV71-infected children with cardiopulmonary failure. Copyright ? 2005 by Lippincott Williams & Wilkins. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-17144369122&doi=10.1097%2f01.inf.0000157219.19674.98&partnerID=40&md5=0c40c7f5fdbb6cfb1c4fd55862c1a777 https://scholars.lib.ntu.edu.tw/handle/123456789/525667 |
ISSN: | 0891-3668 | DOI: | 10.1097/01.inf.0000157219.19674.98 | SDG/關鍵字: | adrenalin; dobutamine; dopamine; milrinone; troponin I; age distribution; article; atrophy; cerebrospinal fluid; child; clinical article; controlled study; correlation analysis; data analysis; dysphagia; Enterovirus 71; Enterovirus infection; female; heart failure; human; hypotension; hypoventilation; infant; leukocyte count; limb disease; lung insufficiency; male; muscle weakness; outcomes research; prediction; priority journal; systolic blood pressure; treatment outcome; ventilator; virus isolation; Child; Enterovirus; Enterovirus Infections; Female; Heart Arrest; Humans; Infant; Male; Prognosis; Severity of Illness Index; Ventilators, Mechanical |
顯示於: | 醫學系 |
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