https://scholars.lib.ntu.edu.tw/handle/123456789/525670
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | LI-MIN HUANG | en_US |
dc.contributor.author | LUAN-YIN CHANG | en_US |
dc.contributor.author | Tang H. | en_US |
dc.contributor.author | Bock H.L. | en_US |
dc.contributor.author | CHUN-YI LU | en_US |
dc.contributor.author | Huang F.-Y. | en_US |
dc.contributor.author | Lin T.-Y. | en_US |
dc.contributor.author | Lee C.-Y. | en_US |
dc.creator | Huang L.-M.;Luan-Yin Chang;Tang H.;Bock H.L.;Lu C.-Y.;Huang F.-Y.;Lin T.-Y.;Lee C.-Y. | - |
dc.date.accessioned | 2020-12-15T07:42:33Z | - |
dc.date.available | 2020-12-15T07:42:33Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1054-139X | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-27944432479&doi=10.1016%2fj.jadohealth.2005.08.009&partnerID=40&md5=ed5190ed49567d39eab2ebf10547af6d | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/525670 | - |
dc.description.abstract | Purpose: Disease caused by Bordetella pertussis is increasingly being identified among older children and adults in immunized populations, indicating a waning of the vaccine-induced immunity. These findings suggest the need for booster immunization of older children and adults. Modern acellular reduced-antigen-content vaccines have been developed, which can be given as a booster in individuals more than 4 years of age. This study was to assess the immunogenicity and reactogenicity of Boostrix?, GlaxoSmithKline Biologicals' reduced-antigen-content diphtheria-tetanus acellular pertussis (dTpa) vaccine, when administered as a booster in healthy subjects previously primed with DTP vaccine. Methods: Healthy Taiwanese children and adolescents aged 6-8 years and 15-20 years, previously primed with DTP vaccine, were enrolled. All received one dose of Boostrix?. Two blood samples were taken from each of them, one before vaccination and one at 1 month after vaccination. Serum antibodies to diphtheria and tetanus toxoids and immunoglobulin G (IgG) antibodies against the pertussis components PT, FHA and PRN were measured by enzyme-linked immunosorbent assay (ELISA) technique. Adverse reactions following vaccination were recorded. Results: A total of 180 subjects were recruited. The vaccine response rates to the pertussis antigens ranged between 89.0-100%. There were no serious adverse events reported during the study period. Conclusions: The results of this study suggest that Boostrix? may be safely and effectively administered as a booster dose to children previously primed with DTP vaccine. ? 2005 Society for Adolescent Medicine. All rights reserved. | - |
dc.publisher | Elsevier USA | - |
dc.relation.ispartof | Journal of Adolescent Health | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | antigen; diphtheria pertussis tetanus vaccine; filamentous hemagglutinin; hemagglutinin; immunoglobulin G antibody; pertactin; pertussis toxin; tetanus toxoid; unclassified drug; adolescent; adult; antibody blood level; article; blood sampling; child; clinical trial; diphtheria; drug induced disease; drug response; edema; enzyme linked immunosorbent assay; fatigue; female; fever; gastrointestinal symptom; headache; human; human tissue; immunogenicity; male; normal human; pain; pertussis; priority journal; protein content; tetanus; vaccination | - |
dc.title | Immunogenicity and reactogenicity of a reduced-antigen-content diphtheria-tetanus-acellular pertussis vaccine in healthy Taiwanese children and adolescents | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.jadohealth.2005.08.009 | - |
dc.identifier.pmid | 16310132 | - |
dc.identifier.scopus | 2-s2.0-27944432479 | - |
dc.relation.pages | 517 | - |
dc.relation.journalvolume | 37 | - |
dc.relation.journalissue | 6 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | National Taiwan University Children's Hospital | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.orcid | 0000-0002-9291-260X | - |
crisitem.author.orcid | 0000-0003-2632-1956 | - |
crisitem.author.orcid | 0000-0002-5240-2808 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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