https://scholars.lib.ntu.edu.tw/handle/123456789/526433
標題: | Successful treatment of disseminated mixed invasive fungal infection after hematopoietic stem cell transplantation for severe aplastic anemia | 作者: | Weng T.-F. Ho M.-W. Lin H.-C. MENG-YAO LU Peng C.-T. Wu K.-H. |
關鍵字: | aplastic anemia; aspergillosis; hematopoietic stem cell transplantation; zygomycosis | 公開日期: | 2012 | 卷: | 16 | 期: | 2 | 起(迄)頁: | E35-E38 | 來源出版物: | Pediatric Transplantation | 摘要: | Concomitant infections are frequent and usually the causes of death in patients with severe AA. HSCT can restore hematopoiesis in AA, but it is usually life threatening when patients simultaneously have an IFI. Mixed IFIs have been reported on rare occasions. The exact diagnosis of IFIs is difficult because of low fungus culture rate, difficultly obtaining tissue specimens in severely immunocompromised patients or those with bleeding tendencies. Otherwise, treatment with anti-fungal drugs alone for DMIFI was always lethal in previous reports. Surgical resection is crucial for invasive zygomycosis, but severe pancytopenia and bleeding tendency make therapy difficult. Herein, we report that with a combination of aggressive anti-fungal drugs, HSCT, and surgery, we successfully treated a 10-yr-old boy with severe AA and pulmonary zygomycosis before HSCT and disseminated mixed invasive zygomycosis and aspergillosis after HSCT. ? 2010 John Wiley & Sons A/S. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863245891&doi=10.1111%2fj.1399-3046.2010.01406.x&partnerID=40&md5=5392ab8f2f285d42c55d66c5c24f5f2a https://scholars.lib.ntu.edu.tw/handle/123456789/526433 |
ISSN: | 1397-3142 | DOI: | 10.1111/j.1399-3046.2010.01406.x | SDG/關鍵字: | amphotericin B lipid complex; cilastatin plus imipenem; cyclophosphamide; cyclosporin; fluconazole; granulocyte colony stimulating factor; methotrexate; methylprednisolone; posaconazole; thymocyte antibody; vancomycin; aplastic anemia; article; aspergillosis; Aspergillus fumigatus; bone marrow biopsy; brain abscess; case report; child; computer assisted tomography; disease severity; drug substitution; drug withdrawal; febrile neutropenia; fungus culture; fungus hyphae; graft versus host reaction; hematopoietic stem cell transplantation; histopathology; human; human tissue; lung abscess; lung mycosis; male; mixed infection; nephrectomy; nuclear magnetic resonance imaging; pancytopenia; Rhizopus; school child; splenectomy; systemic mycosis; treatment outcome; video assisted thoracoscopic surgery; zygomycosis; Anemia, Aplastic; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Child; Combined Modality Therapy; Hematopoietic Stem Cell Transplantation; Humans; Immunocompromised Host; Immunosuppressive Agents; Male; Mucormycosis; Rhizopus; Triazoles |
顯示於: | 醫學系 |
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