https://scholars.lib.ntu.edu.tw/handle/123456789/526481
標題: | Langerhans' cell histiocytosis presenting with a para-aortic lesion and heart failure | 作者: | CHIEN-YI CHEN MEI-HWAN WU Huang S.-F. SHYH-JYE CHEN MENG-YAO LU |
公開日期: | 2001 | 卷: | 100 | 期: | 2 | 起(迄)頁: | 127-130 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Langerhans' cell histiocytosis (LCH) is an uncommon disease with variable manifestations. We report a case of LCH with the unusual initial presentation of chest pain and progressive heart failure in a 5-year-old boy. Chest radiography revealed a wide mediastinum with cardiomegaly. Electrocardiography showed first-degree atrioventricular block and an inverted T wave over V4-V6. Echocardiography, computed tomography, and magnetic resonance imaging of the chest all showed an infiltrating lesion that enveloped the entire heart, great vessels, and coronary arteries. Pathologic examination of the biopsy specimen revealed LCH. Chemotherapy, which included prednisolone, vincristine, methotrexate, and 6-mercaptopurine, had only a minimal effect on the tumor. After the addition of etoposide, the lesion decreased in size, and the symptoms and signs of heart failure and chest pain were ameliorated. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0035025175&partnerID=40&md5=ef240b898b90f2abc63ed5a78fad45ed https://scholars.lib.ntu.edu.tw/handle/123456789/526481 |
ISSN: | 0929-6646 | SDG/關鍵字: | etoposide; mercaptopurine; methotrexate; prednisolone; vincristine; angina pectoris; article; atrioventricular block; cardiomegaly; case report; child; clinical feature; computer assisted tomography; coronary artery; drug response; echocardiography; electrocardiography; great blood vessel; heart failure; histiocytosis; histopathology; human; Langerhans cell; male; mediastinum; nuclear magnetic resonance imaging; symptomatology; T wave; thorax radiography; tumor biopsy; tumor volume; Aortic Diseases; Chest Pain; Child, Preschool; Heart Failure, Congestive; Histiocytosis, Langerhans-Cell; Humans; Male |
顯示於: | 醫學系 |
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