https://scholars.lib.ntu.edu.tw/handle/123456789/526822
標題: | Mortality association between obesity and pneumonia using a dual restricted cohort model | 作者: | Wang H. CHIEN-CHANG LEE Chou E.H. Hsu W.-T. Robinson R.D. Su K.-Y. Kirby J.J. Hassani D. |
關鍵字: | Mortality; Obesity; Pneumonia | 公開日期: | 2020 | 卷: | 14 | 期: | 4 | 起(迄)頁: | 350-359 | 來源出版物: | Obesity Research and Clinical Practice | 摘要: | Background: An obesity survival paradox has been reported among obese patients with pneumonia. Aims: To determine the impact of obesity on pneumonia outcomes and analyze the correlation between in-hospital all-cause mortality and obesity among patients with pneumonia. Methods: The United States Nationwide Readmissions Database (NRD) was retrospectively analyzed for patients with pneumonia from 2013 to 2014. We used a step-wise restricted and propensity score matching cohort model (dual model) to compare mortality rates and other outcomes among pneumonia patients based on BMI. Mortality was calculated by a Cox proportional hazard model, adjusted for potential confounders with propensity score matched analysis. Results: A total of 70,886,775 patients were registered in NRD during the study period. Of these, 7,786,913 patients (11.0%) were considered obese and 1,652,456 patients (2.3%) were admitted to the hospital with pneumonia. Based on the step-wise restricted cohort model, the hazard ratio comparing the mortality rates among obese pneumonia patients to mortality rates among normal BMI pneumonia patients was 0.75 (95% CI 0.60–0.94). The propensity score matched analysis estimated a hazard rate of 0.84 (95% CI 0.79–0.90) and the hazard ratio estimated from the dual model was 0.82 (95% CI 0.63–1.07). Conclusions: With the application of a dual model, there appears to be no significant difference in mortality of obese patients with pneumonia compared to normal BMI patients with pneumonia. ? 2020 |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/526822 | ISSN: | 1871-403X | DOI: | 10.1016/j.orcp.2019.09.007 | SDG/關鍵字: | adult; aged; all cause mortality; Article; body mass; clinical outcome; cohort analysis; comparative study; confounding variable; controlled study; correlation coefficient; data base; disease association; female; hazard ratio; hospital admission; hospital mortality; hospital patient; human; major clinical study; male; middle aged; mortality rate; obese patient; obesity; observational study; pneumonia; priority journal; prognosis; propensity score; proportional hazards model; retrospective study; step wise multiple regression; very elderly; complication; mortality; United States; Body Mass Index; Cohort Studies; Humans; Obesity; Pneumonia; Proportional Hazards Models; Retrospective Studies; United States |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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